Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. ILROG Lymphoma Mini-Atlas Part II, Hodgkin Lymphoma

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Development of depression in patients with oral cavity cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.

METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.

RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.

CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

OriginalsprogEngelsk
TidsskriftHead and Neck
Vol/bind42
Udgave nummer11
Sider (fra-til)3161-3170
ISSN1043-3074
DOI
StatusUdgivet - 1 nov. 2020

Bibliografisk note

© 2020 Wiley Periodicals LLC.

ID: 60986039