Osteogenesis imperfecta type V: marked phenotypic variability despite the presence of the IFITM5 c.-14C>T mutation in all patients

Frank Rauch, Pierre Moffatt, Moira Cheung, Peter Roughley, Liljana Lalic, Allan M Lund, Norman Ramirez, Somayyeh Fahiminiya, Jacek Majewski, Francis H Glorieux

101 Citationer (Scopus)

Abstract

Osteogenesis imperfecta (OI) type V is an autosomal dominant bone fragility disorder that we had described a decade ago. Recent research has shown that OI type V is caused by a recurrent c.-14C>T mutation in IFITM5. In the present study, we assessed all patients diagnosed with OI type V at our institutions for the presence of the IFITM5 mutation.
OriginalsprogEngelsk
TidsskriftJournal of Medical Genetics
Vol/bind50
Udgave nummer1
Sider (fra-til)21-4
Antal sider4
ISSN0022-2593
DOI
StatusUdgivet - jan. 2013

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