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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Orbital lymphoma

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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  4. Malignant lymphoma of the conjunctiva

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  5. The role of inflammation in the pathogenesis of glaucoma

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  1. Inverted papilloma of the conjunctiva

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  2. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Periocular necrotizing soft tissue infection in Greater Copenhagen

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  4. A presentation of culture-positive corneal donors and the effect on clinical outcomes

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    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginal zone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (23%), follicular lymphoma (9%), and mantle cell lymphoma (5%). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype. However, extranodal marginal zone B-cell lymphoma (53%) and follicular lymphoma (75%) show a female predominance, whereas diffuse large B-cell lymphoma shows an even gender distribution. Mantle cell lymphoma has a striking male predominance of 80%. The histopathological subtype and the clinical stage of the disease are the best indicators of prognosis and patient outcome. Low-grade lymphomas such as extranodal marginal zone B-cell lymphoma and FL have a good prognosis, whereas high-grade lymphomas (diffuse large B-cell lymphoma and mantle cell lymphoma) are associated with a poor prognosis. When managing solitary low-grade lymphomas, radiotherapy is the treatment of choice. Chemotherapy, with or without radiotherapy, should be chosen for disseminated and high-grade lymphomas.

OriginalsprogEngelsk
TidsskriftSurvey of Ophthalmology
Vol/bind64
Udgave nummer1
Sider (fra-til)45-66
Antal sider22
ISSN0039-6257
DOI
StatusUdgivet - jan. 2019

ID: 56468532