TY - JOUR
T1 - Oral Erythritol Reduces Energy Intake during a Subsequent ad libitum Test Meal
T2 - A Randomized, Controlled, Crossover Trial in Healthy Humans
AU - Teysseire, Fabienne
AU - Flad, Emilie
AU - Bordier, Valentine
AU - Budzinska, Aleksandra
AU - Weltens, Nathalie
AU - Rehfeld, Jens F
AU - Beglinger, Christoph
AU - Van Oudenhove, Lukas
AU - Wölnerhanssen, Bettina K
AU - Meyer-Gerspach, Anne Christin
PY - 2022/9/21
Y1 - 2022/9/21
N2 - The impact of oral erythritol on subsequent energy intake is unknown. The aim was to assess the effect of oral erythritol compared to sucrose, sucralose, or tap water on energy intake during a subsequent ad libitum test meal and to examine the release of cholecystokinin (CCK) in response to these substances. In this randomized, crossover trial, 20 healthy volunteers received 50 g erythritol, 33.5 g sucrose, or 0.0558 g sucralose dissolved in tap water, or tap water as an oral preload in four different sessions. Fifteen minutes later, a test meal was served and energy intake was assessed. At set time points, blood samples were collected to quantify CCK concentrations. The energy intake (ad libitum test meal) was significantly lower after erythritol compared to sucrose, sucralose, or tap water (p < 0.05). Before the start of the ad libitum test meal, erythritol led to a significant increase in CCK compared to sucrose, sucralose, or tap water (p < 0.001). Oral erythritol given alone induced the release of CCK before the start of the ad libitum test meal and reduced subsequent energy intake compared to sucrose, sucralose, or tap water. These properties make erythritol a useful sugar alternative.
AB - The impact of oral erythritol on subsequent energy intake is unknown. The aim was to assess the effect of oral erythritol compared to sucrose, sucralose, or tap water on energy intake during a subsequent ad libitum test meal and to examine the release of cholecystokinin (CCK) in response to these substances. In this randomized, crossover trial, 20 healthy volunteers received 50 g erythritol, 33.5 g sucrose, or 0.0558 g sucralose dissolved in tap water, or tap water as an oral preload in four different sessions. Fifteen minutes later, a test meal was served and energy intake was assessed. At set time points, blood samples were collected to quantify CCK concentrations. The energy intake (ad libitum test meal) was significantly lower after erythritol compared to sucrose, sucralose, or tap water (p < 0.05). Before the start of the ad libitum test meal, erythritol led to a significant increase in CCK compared to sucrose, sucralose, or tap water (p < 0.001). Oral erythritol given alone induced the release of CCK before the start of the ad libitum test meal and reduced subsequent energy intake compared to sucrose, sucralose, or tap water. These properties make erythritol a useful sugar alternative.
KW - Cholecystokinin
KW - Cross-Over Studies
KW - Energy Intake/physiology
KW - Erythritol/pharmacology
KW - Humans
KW - Sucrose/pharmacology
KW - Water/pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85139865664&partnerID=8YFLogxK
U2 - 10.3390/nu14193918
DO - 10.3390/nu14193918
M3 - Journal article
C2 - 36235571
SN - 2072-6643
VL - 14
JO - Nutrients
JF - Nutrients
IS - 19
M1 - 3918
ER -