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Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

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  • Nikolaj Rittig
  • Mads Svart
  • Henrik Holm Thomsen
  • Esben Thyssen Vestergaard
  • Jens Frederik Rehfeld
  • Bolette Hartmann
  • Jens Juul Holst
  • Mogens Johannsen
  • Niels Møller
  • Niels Jessen
Vis graf over relationer

BACKGROUND: D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also as an important signaling metabolite. Oral ketone supplements containing D/L-3-OHB are becoming a popular approach to achieve ketosis.

AIM: To explore the gut-derived effects of ketone supplements.

METHODS: Eight healthy lean male volunteers were investigated on 2 separate occasions:An acetaminophen test was performed to evaluate gastric emptying and blood samples were obtained consecutively throughout the study period.

RESULTS: We show that oral consumption of D/L-3-OHB stimulates cholecystokinin release (P = 0.02), elevates insulin (P = 0.03) and C-peptide (P < 0.001) concentrations, and slows gastric emptying (P = 0.01) compared with matched intravenous D/L-3-OHB administration. Measures of appetite and plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were unaffected by interventions.

CONCLUSION: Our findings show that D/L-3-OHB exert incretin effects and indicate luminal sensing in the gut endothelium. This adds to our understanding of ketones as signaling metabolites and displays the important difference between physiological ketosis and oral ketone supplements.

OriginalsprogEngelsk
Artikelnummerdgaa483
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind105
Udgave nummer10
Antal sider9
ISSN0021-972X
DOI
StatusUdgivet - 1 okt. 2020

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© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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