Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

M Nygaard; D Hovgaard; I M Schjødt; N S Andersen; L Vindeløv; H Sengeløv

doi:10.1111/jcpt.12266

Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

M Nygaard, D Hovgaard, I M Schjødt, N S Andersen, L Vindeløv, H Sengeløv

1 Citationer (Scopus)

Abstract

WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.

CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.

WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Pharmacy and Therapeutics
Vol/bind	40
Udgave nummer	3
Sider (fra-til)	358-61
Antal sider	4
ISSN	0269-4727
DOI	https://doi.org/10.1111/jcpt.12266
Status	Udgivet - jun. 2015

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10.1111/jcpt.12266

Citationsformater

@article{f14960abdb4643a7af9b65d1ce99284e,

title = "Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation",

abstract = "WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.",

keywords = "Administration, Oral, Adolescent, Adult, Cyclosporine, Drug Monitoring, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppressive Agents, Incidence, Male, Middle Aged, Retrospective Studies, Transplantation Conditioning, Young Adult",

author = "M Nygaard and D Hovgaard and Schj{\o}dt, {I M} and Andersen, {N S} and L Vindel{\o}v and H Sengel{\o}v",

note = "{\textcopyright} 2015 John Wiley & Sons Ltd.",

year = "2015",

month = jun,

doi = "10.1111/jcpt.12266",

language = "English",

volume = "40",

pages = "358--61",

journal = "Journal of Clinical Pharmacy and Therapeutics",

issn = "0269-4727",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

AU - Nygaard, M

AU - Hovgaard, D

AU - Schjødt, I M

AU - Andersen, N S

AU - Vindeløv, L

AU - Sengeløv, H

PY - 2015/6

Y1 - 2015/6

N2 - WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

AB - WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

KW - Administration, Oral

KW - Adolescent

KW - Adult

KW - Cyclosporine

KW - Drug Monitoring

KW - Female

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Immunosuppressive Agents

KW - Incidence

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Transplantation Conditioning

KW - Young Adult

U2 - 10.1111/jcpt.12266

DO - 10.1111/jcpt.12266

M3 - Journal article

C2 - 25829023

SN - 0269-4727

VL - 40

SP - 358

EP - 361

JO - Journal of Clinical Pharmacy and Therapeutics

JF - Journal of Clinical Pharmacy and Therapeutics

IS - 3

ER -

Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

Abstract

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