Oral branched-chain amino acids do not improve exercise capacity in McArdle disease

D MacLean, J Vissing, S F Vissing, R G Haller

Abstract

To determine whether oral branched-chain amino acids (BCAAs) improve exercise capacity, six fasting patients with McArdle's disease were given a solution of BCAA (77 mg/kg) or a control noncaloric beverage 30 minutes before exercise. The BCAA meal tripled plasma BCAA levels, increased BCAA catabolism as indicated by greater exercise increases in plasma glutamine and alanine, but lowered mean peak free fatty acid levels and reduced exercise capacity in five of six patients. Lower work capacity may be attributed to a net reduction in muscle fuel availability after BCAA administration.

OriginalsprogEngelsk
TidsskriftNeurology
Vol/bind51
Udgave nummer5
Sider (fra-til)1456-9
Antal sider4
ISSN0028-3878
DOI
StatusUdgivet - nov. 1998
Udgivet eksterntJa

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