Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15

Forskning

Udskriv

Switch language

Region Hovedstaden - en del af Københavns Universitetshospital

E-pub ahead of print

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bibtex

@article{1494b3ca394a47cf9d7767275296aa19,

title = "Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15",

abstract = "INTRODUCTION: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV.METHODS: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis.RESULTS: Among 82 MSM, the Nm carriage rate was 31.7 {\%} (95 {\%} CI 21.9-42.9) at baseline. The oral carriage rate was 24.4 {\%} (95 {\%} CI 15.6-35.1) and the anal rate was 11.0 {\%} (95 {\%} CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up.CONCLUSION: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.",

author = "Michaela Tinggaard and Hans-Christian Slotved and Kurt Fuursted and Rosenstierne, {Maiken Wors{\o}e} and Gitte Kronborg and Anne-Mette Lebech and Kristina Thorsteinsson and Katzenstein, {Terese L} and Merete Storgaard and Holden, {Inge Kristine} and Johansen, {Isik Somuncu} and Thomas Benfield",

note = "Copyright {\circledC} 2021. Published by Elsevier Ltd.",

year = "2021",

month = "2",

day = "18",

doi = "10.1016/j.ijid.2021.02.062",

language = "English",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15

AU - Tinggaard, Michaela

AU - Slotved, Hans-Christian

AU - Fuursted, Kurt

AU - Rosenstierne, Maiken Worsøe

AU - Kronborg, Gitte

AU - Lebech, Anne-Mette

AU - Thorsteinsson, Kristina

AU - Katzenstein, Terese L

AU - Storgaard, Merete

AU - Holden, Inge Kristine

AU - Johansen, Isik Somuncu

AU - Benfield, Thomas

PY - 2021/2/18

Y1 - 2021/2/18

N2 - INTRODUCTION: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV.METHODS: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis.RESULTS: Among 82 MSM, the Nm carriage rate was 31.7 % (95 % CI 21.9-42.9) at baseline. The oral carriage rate was 24.4 % (95 % CI 15.6-35.1) and the anal rate was 11.0 % (95 % CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up.CONCLUSION: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.

AB - INTRODUCTION: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV.METHODS: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis.RESULTS: Among 82 MSM, the Nm carriage rate was 31.7 % (95 % CI 21.9-42.9) at baseline. The oral carriage rate was 24.4 % (95 % CI 15.6-35.1) and the anal rate was 11.0 % (95 % CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up.CONCLUSION: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.

U2 - 10.1016/j.ijid.2021.02.062

DO - 10.1016/j.ijid.2021.02.062

M3 - Journal article

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -

ID: 62392378

Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

RIS