Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment

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    Abstract

    Dose-response curves for headaches relief and adverse events (AEs) are presented for five triptans: sumatriptan, zolmitriptan, naratriptan, almotriptan, and frovatriptan, and the CGRP antagonist telcagepant. The upper part of the efficacy curve of the triptans is generally flat, the so-called ceiling effect; and none of the oral triptans, even in high doses, are as effective as subcutaneous sumatriptan, In contrast, AEs increases with increasing dose without a ceiling effect. The optimal dose for the triptans is mainly determined by tolerability. Telcagepant has an excellent tolerability and can be used in migraine patients with cardiovascular co-morbidity. Based on the literature the triptans and telcagepant are rated in a table for efficacy and tolerability.
    OriginalsprogEngelsk
    TidsskriftJournal of Headache and Pain
    Vol/bind12
    Udgave nummer3
    Sider (fra-til)275-80
    Antal sider6
    ISSN1129-2369
    DOI
    StatusUdgivet - 2011

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