Optic neuritis: chemokine receptor CXCR3 and its ligands

T L Sørensen; H Roed; F Sellebjerg

doi:10.1136/bjo.2003.040980

Optic neuritis: chemokine receptor CXCR3 and its ligands

T L Sørensen, H Roed, F Sellebjerg

10 Citationer (Scopus)

Abstract

AIM: To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).

METHODS: 30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (CSF) T cells by flow cytometry. CXCL9, CXCL10, and CXCL11 were measured in plasma and CSF by ELISA.

RESULTS: CSF concentrations of CXCL10, but not of CXCL9 and CXCL11, were significantly higher in ON patients than in controls. CSF concentrations of CXCL10 correlated with the CSF leucocyte count in ON patients, and CXCR3 expressing cells were significantly enriched in the CSF.

CONCLUSION: These data show that the CSF concentration of the CXCR3 ligand CXCL10 is selectively increased in CSF from ON patients, and CXCR3 positive cells are recruited to the subarachnoid space.

Originalsprog	Engelsk
Tidsskrift	The British journal of ophthalmology
Vol/bind	88
Udgave nummer	9
Sider (fra-til)	1146-8
Antal sider	3
ISSN	0007-1161
DOI	https://doi.org/10.1136/bjo.2003.040980
Status	Udgivet - sep. 2004
Udgivet eksternt	Ja

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10.1136/bjo.2003.040980

Citationsformater

@article{a81ad7df272947a2b1a1cc38697cd436,

title = "Optic neuritis: chemokine receptor CXCR3 and its ligands",

abstract = "AIM: To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).METHODS: 30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (CSF) T cells by flow cytometry. CXCL9, CXCL10, and CXCL11 were measured in plasma and CSF by ELISA.RESULTS: CSF concentrations of CXCL10, but not of CXCL9 and CXCL11, were significantly higher in ON patients than in controls. CSF concentrations of CXCL10 correlated with the CSF leucocyte count in ON patients, and CXCR3 expressing cells were significantly enriched in the CSF.CONCLUSION: These data show that the CSF concentration of the CXCR3 ligand CXCL10 is selectively increased in CSF from ON patients, and CXCR3 positive cells are recruited to the subarachnoid space.",

keywords = "Adult, Chemokine CXCL10, Chemokine CXCL11, Chemokine CXCL9, Chemokines, CXC/blood, Female, Humans, Intercellular Signaling Peptides and Proteins/blood, Ligands, Male, Middle Aged, Optic Neuritis/blood, Receptors, CXCR3, Receptors, Chemokine/blood, T-Lymphocytes/metabolism",

author = "S{\o}rensen, {T L} and H Roed and F Sellebjerg",

year = "2004",

month = sep,

doi = "10.1136/bjo.2003.040980",

language = "English",

volume = "88",

pages = "1146--8",

journal = "The British journal of ophthalmology",

issn = "0007-1161",

publisher = "B M J Group",

number = "9",

}

TY - JOUR

T1 - Optic neuritis

T2 - chemokine receptor CXCR3 and its ligands

AU - Sørensen, T L

AU - Roed, H

AU - Sellebjerg, F

PY - 2004/9

Y1 - 2004/9

N2 - AIM: To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).METHODS: 30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (CSF) T cells by flow cytometry. CXCL9, CXCL10, and CXCL11 were measured in plasma and CSF by ELISA.RESULTS: CSF concentrations of CXCL10, but not of CXCL9 and CXCL11, were significantly higher in ON patients than in controls. CSF concentrations of CXCL10 correlated with the CSF leucocyte count in ON patients, and CXCR3 expressing cells were significantly enriched in the CSF.CONCLUSION: These data show that the CSF concentration of the CXCR3 ligand CXCL10 is selectively increased in CSF from ON patients, and CXCR3 positive cells are recruited to the subarachnoid space.

AB - AIM: To study the involvement of the chemokine receptor CXCR3 and its ligands (CXCL9/Mig, CXCL10/IP-10, CXCL11/ITAC) in optic neuritis (ON).METHODS: 30 patients with ON and 10 non-inflammatory neurological disease controls were included. The patients underwent a phlebotomy, lumbar puncture, and MRI scan. CXCR3 expression was studied on blood and cerebrospinal fluid (CSF) T cells by flow cytometry. CXCL9, CXCL10, and CXCL11 were measured in plasma and CSF by ELISA.RESULTS: CSF concentrations of CXCL10, but not of CXCL9 and CXCL11, were significantly higher in ON patients than in controls. CSF concentrations of CXCL10 correlated with the CSF leucocyte count in ON patients, and CXCR3 expressing cells were significantly enriched in the CSF.CONCLUSION: These data show that the CSF concentration of the CXCR3 ligand CXCL10 is selectively increased in CSF from ON patients, and CXCR3 positive cells are recruited to the subarachnoid space.

KW - Adult

KW - Chemokine CXCL10

KW - Chemokine CXCL11

KW - Chemokine CXCL9

KW - Chemokines, CXC/blood

KW - Female

KW - Humans

KW - Intercellular Signaling Peptides and Proteins/blood

KW - Ligands

KW - Male

KW - Middle Aged

KW - Optic Neuritis/blood

KW - Receptors, CXCR3

KW - Receptors, Chemokine/blood

KW - T-Lymphocytes/metabolism

U2 - 10.1136/bjo.2003.040980

DO - 10.1136/bjo.2003.040980

M3 - Journal article

C2 - 15317705

SN - 0007-1161

VL - 88

SP - 1146

EP - 1148

JO - The British journal of ophthalmology

JF - The British journal of ophthalmology

IS - 9

ER -

Optic neuritis: chemokine receptor CXCR3 and its ligands

Abstract

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