Ontogeny of procholecystokinin processing in rat hypothalamus

N W Mogensen, L Hilsted, L Bardram, J F Rehfeld

7 Citationer (Scopus)

Abstract

The concentration of procholecystokinin (pro-CCK) in the fetal hypothalamus was 126 +/- 41 pmol/g (mean +/- SEM; n = 20), 22 +/- 9 pmol/g at day 7 postpartum and 3 +/- 2 pmol/g in the adult. In contrast, the concentration of bioactive carboxyamidated CCK rose from 6 +/- 2 pmol/g in the fetal hypothalamus to 52 +/- 10 pmol/g in the adult. The concentration of glycine-extended processing intermediates first decreased from 21 +/- 5 pmol/g in the fetus to 5 +/- 1 pmol/g at day 21 postpartum. Subsequently, the concentration rose to 21 +/- 4 pmol/g in the adult. The results show that the CCK gene is well expressed in the fetal hypothalamus. However, only a small fraction of pro-CCK reaches maturation before weaning. We conclude that expression of the CCK gene in the hypothalamus as bioactive peptide to a large degree is regulated at the posttranslational level.

OriginalsprogEngelsk
TidsskriftDevelopmental Neuroscience
Vol/bind13
Udgave nummer2
Sider (fra-til)104-9
Antal sider6
ISSN0378-5866
DOI
StatusUdgivet - 1991
Udgivet eksterntJa

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