Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Oncology to specialised palliative home care systematic transition: the Domus randomised trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Bereaved caregivers of patients with high-grade glioma: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Validation of a Battery of Neuropsychological Tests for Patients With Metastatic Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Depressive Symptoms in Danish Patients With Glioma and a Cancer-Free Comparison Group

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Total burden of disease in cancer patients at diagnosis-a Danish nationwide study of multimorbidity and redeemed medication

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. eHealth-mind the gap

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: To assess the effect of a systematic, fast-track transition from oncological treatment to specialised palliative care at home on symptom burden, to explore intervention mechanisms through patient and intervention provider characteristics and to assess long-term survival and place of death.

MEASURES: The effect of a systematic, fast-track transition from oncological treatment to specialised palliative care at home on patient symptom burden was studied in the Domus randomised clinical trial. Participants had incurable cancer and limited treatment options. The intervention was provided by specialised palliative home teams (SPT) based in hospice or hospital and was enriched with a psychological intervention for patient and caregiver dyad. Symptom burden was measured with Edmonton Symptom Assessment System (ESAS-r) at baseline, 8 weeks and 6 months follow-up and analysed with mixed models. Survival and place of death was analysed with Kaplan-Meier and Fisher's exact tests.

RESULTS: The study included 322 patients. Tiredness was significantly improved for the Domus intervention group at 6 months while the other nine symptom outcomes were not significantly different from the control group. Exploring the efficacy of intervention provider demonstrated significant differences in favour of the hospice SPT on four symptoms and total symptom score. Patients with children responded more favourably to the intervention. The long-term follow-up demonstrated no differences between the intervention and the control groups regarding survival or home deaths.

CONCLUSIONS: The Domus intervention may reduce tiredness. Moreover, the intervention provider and having children might play a role concerning intervention efficacy. The intervention did not affect survival or home deaths.

TRIAL REGISTRATION NUMBER: NCT01885637.

OriginalsprogEngelsk
TidsskriftBMJ Supportive and Palliative Care
Vol/bind10
Udgave nummer3
Sider (fra-til)350-357
Antal sider8
ISSN2045-435X
DOI
StatusUdgivet - sep. 2020

Bibliografisk note

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 60408878