@article{942273ae9ae0406ca11e696431381c26,
title = "On the pathogenesis of IDDM",
abstract = "A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.",
keywords = "Animals, Awards and Prizes, Denmark, Diabetes Mellitus, Diabetes Mellitus, Type 1, Europe, History, 20th Century, Humans, Interleukin-1, Islets of Langerhans, Models, Biological, Nitric Oxide, Receptors, Interleukin-1, Societies, Medical, Superoxides",
author = "J Nerup and Thomas Mandrup-Poulsen and S Helqvist and Andersen, {H U} and F Pociot and Reimers, {J I} and Cuartero, {B G} and Karlsen, {A E} and U Bjerre and T Lorenzen",
year = "1994",
month = sep,
language = "English",
volume = "37 Suppl 2",
pages = "S82--9",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
}