Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy

Kathleen A Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bønnelykke, Hans Bisgaard, Bo Chawes, Rachel S Kelly, Jessica Lasky-Su, Robert S Zeiger, George T O'Connor, Leonard B Bacharier, Vincent J Carey, Nancy Laranjo, Augusto A Litonjua, Scott T Weiss

1 Citationer (Scopus)

Abstract

Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region.

OriginalsprogEngelsk
Artikelnummer2416
TidsskriftNutrients
Vol/bind15
Udgave nummer10
ISSN2072-6643
DOI
StatusUdgivet - 22 maj 2023

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