Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis

Alison McLaverty; Kelly A Allott; Maximus Berger; Rob Hester; Patrick D McGorry; Barnaby Nelson; Connie Markulev; Hok Pan Yuen; Miriam R Schäfer; Nilufar Mossaheb; Monika Schlögelhofer; Stefan Smesny; Ian B Hickie; Gregor Emanuel Berger; Eric Y H Chen; Lieuwe de Haan; Dorien H Nieman; Merete Nordentoft; Anita Riecher-Rössler; Swapna Verma; Andrew Thompson; Alison Ruth Yung; G Paul Amminger

doi:10.1111/eip.13025

Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis

Alison McLaverty, Kelly A Allott, Maximus Berger, Rob Hester, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna VermaAndrew Thompson, Alison Ruth Yung, G Paul Amminger

11 Citationer (Scopus)

Abstract

BACKGROUND: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.

METHOD: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.

RESULTS: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007).

CONCLUSIONS: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.

Originalsprog	Engelsk
Tidsskrift	Early Intervention in Psychiatry
Vol/bind	15
Udgave nummer	4
Sider (fra-til)	874-881
Antal sider	8
ISSN	1751-7885
DOI	https://doi.org/10.1111/eip.13025
Status	Udgivet - aug. 2021

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10.1111/eip.13025

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McLaverty, A., Allott, K. A., Berger, M., Hester, R., McGorry, P. D., Nelson, B., Markulev, C., Yuen, H. P., Schäfer, M. R., Mossaheb, N., Schlögelhofer, M., Smesny, S., Hickie, I. B., Berger, G. E., Chen, E. Y. H., de Haan, L., Nieman, D. H., Nordentoft, M., Riecher-Rössler, A., ... Amminger, G. P. (2021). Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis. Early Intervention in Psychiatry, 15(4), 874-881. https://doi.org/10.1111/eip.13025

McLaverty, A, Allott, KA, Berger, M, Hester, R, McGorry, PD, Nelson, B, Markulev, C, Yuen, HP, Schäfer, MR, Mossaheb, N, Schlögelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rössler, A, Verma, S, Thompson, A, Yung, AR & Amminger, GP 2021, 'Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis', Early Intervention in Psychiatry, bind 15, nr. 4, s. 874-881. https://doi.org/10.1111/eip.13025

@article{69a95c85129e474190885d56d911a674,

title = "Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis",

abstract = "BACKGROUND: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.METHOD: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.RESULTS: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007).CONCLUSIONS: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.",

keywords = "neurocognition, omega-3, poly-unsaturated fatty acids, ultra-high risk",

author = "Alison McLaverty and Allott, {Kelly A} and Maximus Berger and Rob Hester and McGorry, {Patrick D} and Barnaby Nelson and Connie Markulev and Yuen, {Hok Pan} and Sch{\"a}fer, {Miriam R} and Nilufar Mossaheb and Monika Schl{\"o}gelhofer and Stefan Smesny and Hickie, {Ian B} and Berger, {Gregor Emanuel} and Chen, {Eric Y H} and {de Haan}, Lieuwe and Nieman, {Dorien H} and Merete Nordentoft and Anita Riecher-R{\"o}ssler and Swapna Verma and Andrew Thompson and Yung, {Alison Ruth} and Amminger, {G Paul}",

note = "{\textcopyright} 2020 John Wiley & Sons Australia, Ltd.",

year = "2021",

month = aug,

doi = "10.1111/eip.13025",

language = "English",

volume = "15",

pages = "874--881",

journal = "Early Intervention in Psychiatry",

issn = "1751-7885",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis

AU - McLaverty, Alison

AU - Allott, Kelly A

AU - Berger, Maximus

AU - Hester, Rob

AU - McGorry, Patrick D

AU - Nelson, Barnaby

AU - Markulev, Connie

AU - Yuen, Hok Pan

AU - Schäfer, Miriam R

AU - Mossaheb, Nilufar

AU - Schlögelhofer, Monika

AU - Smesny, Stefan

AU - Hickie, Ian B

AU - Berger, Gregor Emanuel

AU - Chen, Eric Y H

AU - de Haan, Lieuwe

AU - Nieman, Dorien H

AU - Nordentoft, Merete

AU - Riecher-Rössler, Anita

AU - Verma, Swapna

AU - Thompson, Andrew

AU - Yung, Alison Ruth

AU - Amminger, G Paul

PY - 2021/8

Y1 - 2021/8

N2 - BACKGROUND: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.METHOD: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.RESULTS: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007).CONCLUSIONS: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.

AB - BACKGROUND: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.METHOD: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.RESULTS: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007).CONCLUSIONS: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.

KW - neurocognition

KW - omega-3

KW - poly-unsaturated fatty acids

KW - ultra-high risk

UR - http://www.scopus.com/inward/record.url?scp=85090248853&partnerID=8YFLogxK

U2 - 10.1111/eip.13025

DO - 10.1111/eip.13025

M3 - Journal article

C2 - 32893462

SN - 1751-7885

VL - 15

SP - 874

EP - 881

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

IS - 4

ER -

Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis

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