Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Ocular Adnexal Diffuse Large B-cell Lymphoma: A Multicenter International Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Association of Choroidal Effusion and Infusion of Daratumumab

    Publikation: Bidrag til tidsskriftLetterForskning

  2. Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Age-Related Macular Degeneration in Patients With Chronic Myeloproliferative Neoplasms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Association of Choroidal Effusion and Infusion of Daratumumab

    Publikation: Bidrag til tidsskriftLetterForskning

  2. Inverted papilloma of the conjunctiva

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Periocular necrotizing soft tissue infection in Greater Copenhagen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A presentation of culture-positive corneal donors and the effect on clinical outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Importance: The clinical features of diffuse large B-cell lymphoma (DLBCL) subtype of ocular adnexal lymphoma have not previously been evaluated in a large cohort to our knowledge.

Objective: To investigate the clinical features of ocular adnexal DLBCL (OA-DLBCL).

Design, Setting, and Participants: This retrospective international cooperative study involved 6 eye cancer centers. During 30 years, 106 patients with OA-DLBCL were identified, and 6 were excluded from the study. The median follow-up period was 52 months.

Main Outcomes and Measures: Overall survival, disease-specific survival (DSS), and progression-free survival were the primary end points.

Results: One hundred patients with OA-DLBCL were included in the study (median age, 70 years), of whom 54 (54.0%) were female. The following 3 groups of patients with lymphoma could be identified: primary OA-DLBCL (57.0%), OA-DLBCL and concurrent systemic lymphoma (29.0%), and ocular adnexal lymphoma relapse of previous systemic lymphoma (14.0%). Of 57 patients with primary OA-DLBCL, 53 (93.0%) had Ann Arbor stage IE disease, and 4 (7.0%) had Ann Arbor stage IIE disease. According to the TNM staging system, 43 of 57 (75.4%) had T2 tumors. Among all patients, the most frequent treatments were external beam radiation therapy with or without surgery (31.0%) and rituximab-cyclophosphamide, hydroxydaunorubicin, vincristine sulfate, prednisone (CHOP) or rituximab-CHOP-like chemotherapy with or without external beam radiation therapy (21.0%). The 5-year overall survival among the entire cohort was 36.0% (median, 3.5 years; 95% CI, 2.5-4.5 years). Relapse occurred in 43.9% (25 of 57) of patients with primary OA-DLBCL. Increasing T category of the TNM staging system was predictive of DSS (P = .04) in primary OA-DLBCL, whereas the Ann Arbor staging system was not. However, when taking all 100 patients into account, Ann Arbor stage was able to predict DSS (P = .01). Women had a longer median DSS than men (9.8 years; 95% CI, 1.9-17.7 years vs 3.3 years; 95% CI, 1.6-5.0; P = .03).

Conclusions and Relevance: Most patients with primary OA-DLBCL were seen with Ann Arbor stage IE and TNM T2 disease. The 5-year overall survival was between 2.5 and 4.5 years, which is the 95% CI around the median of 3.5 years in this cohort. Increasing T category appears to be associated with decreased DSS among patients with primary OA-DLBCL. When taking all patients into account, sex and Ann Arbor stage also seem to be DSS predictors.

OriginalsprogEngelsk
TidsskriftJAMA Ophthalmology
Vol/bind133
Udgave nummer2
Sider (fra-til)165-73
DOI
StatusUdgivet - 2015

ID: 44848315