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Obesity is associated with earlier pubertal onset in boys

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@article{d016899442684cddb685cad27abdf28e,
title = "Obesity is associated with earlier pubertal onset in boys",
abstract = "CONTEXT: Pubertal timing in boys is associated with body mass index (BMI). Studies consistently report an inverse correlation of BMI and pubertal timing within the normal BMI range. However, observations in obese boys are conflicting with different studies reporting either early or delayed pubertal onset in obese boys.OBJECTIVE: We aimed to assess the association of male puberty timing with age-specific BMI (zBMI) in obese boys.DESIGN, SETTING AND PARTICIPANTS: 218 obese boys (zBMI>+2SD, median (range) age at baseline 10.8 (4.2-17.0) yrs were recruited as part of a prospective outpatient childhood obesity intervention program at Nordsj{\ae}llands Hospital, Hiller{\o}d, Denmark between 2009 and 2017. Serving as controls, we included 660 healthy boys participating in the population-based COPENHAGEN Puberty Study (-2SDMAIN OUTCOME MEASURE(S): Timing of testicular volume ≥ 4mL, genital stage ≥2 and pubarche.RESULTS: Mean (95{\%} CI) age of onset in obese boys was: testicular volume ≥4mL: 11.3 yrs (11.0-11.6), genital stage ≥2: 11.6 yrs (11.3-11.9), and pubarche: 11.9 yrs (11.5-12.3). Testicular volume ≥4mL occurred significantly earlier in obese boys compared to controls (-2SDCONCLUSIONS: We demonstrate that testicular enlargement in obese boys occurs significantly earlier compared to a population-based normal-weight reference cohort.",
author = "Busch, {Alexander S} and Brigitte H{\o}jgaard and Hagen, {Casper P} and Grete Teilmann",
note = "{\circledC} Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = "11",
day = "25",
doi = "10.1210/clinem/dgz222",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",

}

RIS

TY - JOUR

T1 - Obesity is associated with earlier pubertal onset in boys

AU - Busch, Alexander S

AU - Højgaard, Brigitte

AU - Hagen, Casper P

AU - Teilmann, Grete

N1 - © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/11/25

Y1 - 2019/11/25

N2 - CONTEXT: Pubertal timing in boys is associated with body mass index (BMI). Studies consistently report an inverse correlation of BMI and pubertal timing within the normal BMI range. However, observations in obese boys are conflicting with different studies reporting either early or delayed pubertal onset in obese boys.OBJECTIVE: We aimed to assess the association of male puberty timing with age-specific BMI (zBMI) in obese boys.DESIGN, SETTING AND PARTICIPANTS: 218 obese boys (zBMI>+2SD, median (range) age at baseline 10.8 (4.2-17.0) yrs were recruited as part of a prospective outpatient childhood obesity intervention program at Nordsjællands Hospital, Hillerød, Denmark between 2009 and 2017. Serving as controls, we included 660 healthy boys participating in the population-based COPENHAGEN Puberty Study (-2SDMAIN OUTCOME MEASURE(S): Timing of testicular volume ≥ 4mL, genital stage ≥2 and pubarche.RESULTS: Mean (95% CI) age of onset in obese boys was: testicular volume ≥4mL: 11.3 yrs (11.0-11.6), genital stage ≥2: 11.6 yrs (11.3-11.9), and pubarche: 11.9 yrs (11.5-12.3). Testicular volume ≥4mL occurred significantly earlier in obese boys compared to controls (-2SDCONCLUSIONS: We demonstrate that testicular enlargement in obese boys occurs significantly earlier compared to a population-based normal-weight reference cohort.

AB - CONTEXT: Pubertal timing in boys is associated with body mass index (BMI). Studies consistently report an inverse correlation of BMI and pubertal timing within the normal BMI range. However, observations in obese boys are conflicting with different studies reporting either early or delayed pubertal onset in obese boys.OBJECTIVE: We aimed to assess the association of male puberty timing with age-specific BMI (zBMI) in obese boys.DESIGN, SETTING AND PARTICIPANTS: 218 obese boys (zBMI>+2SD, median (range) age at baseline 10.8 (4.2-17.0) yrs were recruited as part of a prospective outpatient childhood obesity intervention program at Nordsjællands Hospital, Hillerød, Denmark between 2009 and 2017. Serving as controls, we included 660 healthy boys participating in the population-based COPENHAGEN Puberty Study (-2SDMAIN OUTCOME MEASURE(S): Timing of testicular volume ≥ 4mL, genital stage ≥2 and pubarche.RESULTS: Mean (95% CI) age of onset in obese boys was: testicular volume ≥4mL: 11.3 yrs (11.0-11.6), genital stage ≥2: 11.6 yrs (11.3-11.9), and pubarche: 11.9 yrs (11.5-12.3). Testicular volume ≥4mL occurred significantly earlier in obese boys compared to controls (-2SDCONCLUSIONS: We demonstrate that testicular enlargement in obese boys occurs significantly earlier compared to a population-based normal-weight reference cohort.

U2 - 10.1210/clinem/dgz222

DO - 10.1210/clinem/dgz222

M3 - Journal article

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -

ID: 58495077