Nye retningslinjer for antibiotikadosering til patienter med nedsat nyrefunktion og patienter i haemodialyse

Claus Moser, Thomas Elung-Jensen, Niels Høiby

1 Citationer (Scopus)

Abstract

Dosing of antibiotics in patients with renal insufficiency has almost exclusively been based on pharmacokinetic (PK) parameters, whereas the different pharmacodynamic (PD) parameters of antibiotics have only been sparsely considered. This is not appropriate since antibiotics can be divided into two distinct groups: 1) Time-dependent and 2) Concentration (or total dose) dependent killing of bacteria. In this document revised recommendations based on PK/PD parameters are suggested.

Bidragets oversatte titelNew recommendations for antibiotic dosing in patients with renal insufficiency and in patients undergoing haemodialysis
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind170
Udgave nummer8
Sider (fra-til)629-32
Antal sider4
ISSN0041-5782
StatusUdgivet - 18 feb. 2008
Udgivet eksterntJa

Emneord

  • Anti-Bacterial Agents/administration & dosage
  • Dose-Response Relationship, Drug
  • Humans
  • Microbial Sensitivity Tests
  • Renal Dialysis
  • Renal Insufficiency/drug therapy
  • Time Factors

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