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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Vis graf over relationer

Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

Bidragets oversatte titelNovel hormones related to the calcium and phosphate homeostasis in kidney disease
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind180
Udgave nummer21
Sider (fra-til)V05170353
ISSN0041-5782
StatusUdgivet - 21 maj 2018

ID: 55810927