Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Maria Lerche Mace; Klaus Ølgaard; Eva Lewin

Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Maria Lerche Mace, Klaus Ølgaard, Eva Lewin

Nyresygdomme

Abstract

Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

Bidragets oversatte titel	Novel hormones related to the calcium and phosphate homeostasis in kidney disease
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	180
Udgave nummer	21
Sider (fra-til)	V05170353
ISSN	0041-5782
Status	Udgivet - 21 maj 2018

Citationsformater

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abstract = "Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.",

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T1 - Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

AU - Mace, Maria Lerche

AU - Ølgaard, Klaus

AU - Lewin, Eva

PY - 2018/5/21

Y1 - 2018/5/21

N2 - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

AB - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

M3 - Tidsskriftartikel

C2 - 29804564

SN - 0041-5782

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SP - V05170353

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

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ER -

Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Abstract

Fingeraftryk

Citationsformater