Ny test til diagnostik af tuberkulose

Pernille Ravn; Michala Vaaben Rose; Bolette Søborg; Ase Bengård Andersen

Ny test til diagnostik af tuberkulose

Pernille Ravn
, Michala Vaaben Rose
, Bolette Søborg
, Ase Bengård Andersen

Klinisk Forskningsafdeling

2 Citationer (Scopus)

Abstract

The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
Udgivelsesdato: 2009-Sep-7

Bidragets oversatte titel	New diagnostic test for tuberculosis
Originalsprog	Dansk
Tidsskrift	Ugeskr Laeger
Vol/bind	171
Udgave nummer	37
Sider (fra-til)	2635-9
Antal sider	4
Status	Udgivet - 2009

Citationsformater

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title = "Ny test til diagnostik af tuberkulose",

abstract = "The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88\%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97\%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients. Udgivelsesdato: 2009-Sep-7",

keywords = "Adult, Biological Markers, Child, Contact Tracing, Enzyme-Linked Immunosorbent Assay, Humans, Immunocompromised Host, Interferon-gamma, Mycobacterium tuberculosis, Risk Factors, Sensitivity and Specificity, Tuberculin Test, Tuberculosis",

author = "Pernille Ravn and Rose, \{Michala Vaaben\} and Bolette S{\o}borg and Andersen, \{Ase Beng{\aa}rd\}",

year = "2009",

language = "Dansk",

volume = "171",

pages = "2635--9",

journal = "Ugeskr Laeger",

issn = "1399-4174",

publisher = "Almindelige Danske L{\ae}geforening",

number = "37",

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TY - JOUR

T1 - Ny test til diagnostik af tuberkulose

AU - Ravn, Pernille

AU - Rose, Michala Vaaben

AU - Søborg, Bolette

AU - Andersen, Ase Bengård

PY - 2009

Y1 - 2009

N2 - The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients. Udgivelsesdato: 2009-Sep-7

AB - The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients. Udgivelsesdato: 2009-Sep-7

KW - Adult

KW - Biological Markers

KW - Child

KW - Contact Tracing

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Immunocompromised Host

KW - Interferon-gamma

KW - Mycobacterium tuberculosis

KW - Risk Factors

KW - Sensitivity and Specificity

KW - Tuberculin Test

KW - Tuberculosis

M3 - Tidsskriftartikel

C2 - 19758506

SN - 1399-4174

VL - 171

SP - 2635

EP - 2639

JO - Ugeskr Laeger

JF - Ugeskr Laeger

IS - 37

ER -