Abstract
BACKGROUND: This study presents the number of germ cells and somatic cells in human fetal testes during week 6 to week 9 post conception, i.e. the first weeks following sex differentiation of the testes.
METHODS: One testis with attached mesonephros from each of 10 individual legal abortions was used. After recovery of the fetus, the testes were immediately isolated, fixed and processed for histology. The optical fractionator technique, a stereological method, was utilized to estimate the total number of germ cells in ten testes and somatic cells in six of them.
RESULTS: The number of germ cells per testis increased from approximately 3000 in week 6 to approximately 30000 in week 9. The ratio of germ cells to Sertoli cells was approximately 1:11 and the ratio of germ cells to somatic cells was approximately 1:44 throughout this period.
CONCLUSIONS: For the first time, germ cell and somatic cell number have been determined during early human fetal testis development. Knowledge of the number of germ cells in this period may be very important, because several environmental pollutants are suspected to result in decreased semen quality in men born of mothers exposed to these pollutants during pregnancy.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Human reproduction (Oxford, England) |
| Vol/bind | 18 |
| Udgave nummer | 1 |
| Sider (fra-til) | 13-8 |
| Antal sider | 6 |
| ISSN | 0268-1161 |
| DOI | |
| Status | Udgivet - jan. 2003 |
| Udgivet eksternt | Ja |