NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

Henrik Reinhard; Niels Wiinberg; Peter R Hansen; Andreas Kjær; Claus L Petersen; Kaj Winther; Hans-Henrik Parving; Peter Rossing; Peter Karl Jacobsen

doi:10.1186/1475-2840-10-71

NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

Henrik Reinhard, Niels Wiinberg, Peter R Hansen, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing, Peter Karl Jacobsen

Klinisk Fysiologisk/Nuklearmedicinsk Afd.

25 Citationer (Scopus)

Abstract

Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for atherosclerosis is unclear. We examined the interrelationship between P-NT-proBNP, presence of atherosclerosis and/or vascular dysfunction in the coronary, carotid and peripheral arteries in asymptomatic type 2 diabetic patients with microalbuminuria that received intensive multifactorial treatment. METHODS AND RESULTS: P-NT-proBNP was measured in 200 asymptomatic type 2 patients without known cardiac disease that received intensive multifactorial treatment for CV risk reduction. Patients were examined for coronary, carotid and peripheral atherosclerosis, as defined by coronary calcium score≥400, carotid intima-media thickness (CIMT)>0.90 mm, ankle-brachial index

Originalsprog	Engelsk
Tidsskrift	Cardiovascular Diabetology
Vol/bind	10
Sider (fra-til)	71
ISSN	1475-2840
DOI	https://doi.org/10.1186/1475-2840-10-71
Status	Udgivet - 2011

Adgang til dokumentet

10.1186/1475-2840-10-71

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Citationsformater

Reinhard, H., Wiinberg, N., Hansen, P. R., Kjær, A., Petersen, C. L., Winther, K., Parving, H.-H., Rossing, P., & Jacobsen, P. K. (2011). NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis. Cardiovascular Diabetology, 10, 71. https://doi.org/10.1186/1475-2840-10-71

NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis. / Reinhard, Henrik; Wiinberg, Niels ; Hansen, Peter R et al.
I: Cardiovascular Diabetology, Bind 10, 2011, s. 71.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Reinhard, H, Wiinberg, N , Hansen, PR , Kjær, A , Petersen, CL, Winther, K, Parving, H-H , Rossing, P & Jacobsen, PK 2011, 'NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis', Cardiovascular Diabetology, bind 10, s. 71. https://doi.org/10.1186/1475-2840-10-71

Reinhard H, Wiinberg N , Hansen PR , Kjær A , Petersen CL, Winther K et al. NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis. Cardiovascular Diabetology. 2011;10:71. doi: 10.1186/1475-2840-10-71

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title = "NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis",

abstract = "Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for atherosclerosis is unclear. We examined the interrelationship between P-NT-proBNP, presence of atherosclerosis and/or vascular dysfunction in the coronary, carotid and peripheral arteries in asymptomatic type 2 diabetic patients with microalbuminuria that received intensive multifactorial treatment. METHODS AND RESULTS: P-NT-proBNP was measured in 200 asymptomatic type 2 patients without known cardiac disease that received intensive multifactorial treatment for CV risk reduction. Patients were examined for coronary, carotid and peripheral atherosclerosis, as defined by coronary calcium score≥400, carotid intima-media thickness (CIMT)>0.90 mm, ankle-brachial index",

keywords = "Aged, Albuminuria, Ankle Brachial Index, Biological Markers, Carotid Arteries, Carotid Intima-Media Thickness, Comorbidity, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Hyperemia, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Predictive Value of Tests, Risk Factors",

author = "Henrik Reinhard and Niels Wiinberg and Hansen, {Peter R} and Andreas Kj{\ae}r and Petersen, {Claus L} and Kaj Winther and Hans-Henrik Parving and Peter Rossing and Jacobsen, {Peter Karl}",

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T1 - NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

AU - Reinhard, Henrik

AU - Wiinberg, Niels

AU - Hansen, Peter R

AU - Kjær, Andreas

AU - Petersen, Claus L

AU - Winther, Kaj

AU - Parving, Hans-Henrik

AU - Rossing, Peter

AU - Jacobsen, Peter Karl

PY - 2011

Y1 - 2011

N2 - Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for atherosclerosis is unclear. We examined the interrelationship between P-NT-proBNP, presence of atherosclerosis and/or vascular dysfunction in the coronary, carotid and peripheral arteries in asymptomatic type 2 diabetic patients with microalbuminuria that received intensive multifactorial treatment. METHODS AND RESULTS: P-NT-proBNP was measured in 200 asymptomatic type 2 patients without known cardiac disease that received intensive multifactorial treatment for CV risk reduction. Patients were examined for coronary, carotid and peripheral atherosclerosis, as defined by coronary calcium score≥400, carotid intima-media thickness (CIMT)>0.90 mm, ankle-brachial index

AB - Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for atherosclerosis is unclear. We examined the interrelationship between P-NT-proBNP, presence of atherosclerosis and/or vascular dysfunction in the coronary, carotid and peripheral arteries in asymptomatic type 2 diabetic patients with microalbuminuria that received intensive multifactorial treatment. METHODS AND RESULTS: P-NT-proBNP was measured in 200 asymptomatic type 2 patients without known cardiac disease that received intensive multifactorial treatment for CV risk reduction. Patients were examined for coronary, carotid and peripheral atherosclerosis, as defined by coronary calcium score≥400, carotid intima-media thickness (CIMT)>0.90 mm, ankle-brachial index

KW - Aged

KW - Albuminuria

KW - Ankle Brachial Index

KW - Biological Markers

KW - Carotid Arteries

KW - Carotid Intima-Media Thickness

KW - Comorbidity

KW - Coronary Artery Disease

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Hyperemia

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Predictive Value of Tests

KW - Risk Factors

U2 - 10.1186/1475-2840-10-71

DO - 10.1186/1475-2840-10-71

M3 - Journal article

C2 - 21812947

SN - 1475-2840

VL - 10

SP - 71

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

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