NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

Henrik Reinhard; Peter R Hansen; Niels Wiinberg; Andreas Kjær; Claus L Petersen; Kaj Winther; Hans-Henrik Parving; Peter Rossing; Peter K Jacobsen

doi:10.1186/1475-2840-11-19

NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

Henrik Reinhard, Peter R Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing, Peter K Jacobsen

11 Citationer (Scopus)

Abstract

Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients with microalbuminuria receiving intensive multifactorial treatment.

Originalsprog	Engelsk
Tidsskrift	Cardiovascular Diabetology
Vol/bind	11
Sider (fra-til)	19
ISSN	1475-2840
DOI	https://doi.org/10.1186/1475-2840-11-19
Status	Udgivet - 2012

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10.1186/1475-2840-11-19

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title = "NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients",

abstract = "Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients with microalbuminuria receiving intensive multifactorial treatment.",

keywords = "Aged, Albuminuria, Asymptomatic Diseases, Biological Markers, Coronary Angiography, Coronary Artery Disease, Cross-Sectional Studies, Denmark, Diabetes Complications, Diabetes Mellitus, Type 2, Echocardiography, Doppler, Female, Heart Atria, Humans, Hypertrophy, Left Ventricular, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocardial Perfusion Imaging, Natriuretic Peptide, Brain, Odds Ratio, Peptide Fragments, Predictive Value of Tests, Risk Assessment, Risk Factors, Tomography, X-Ray Computed, Ventricular Dysfunction, Left",

author = "Henrik Reinhard and Hansen, \{Peter R\} and Niels Wiinberg and Andreas Kj{\ae}r and Petersen, \{Claus L\} and Kaj Winther and Hans-Henrik Parving and Peter Rossing and Jacobsen, \{Peter K\}",

year = "2012",

doi = "10.1186/1475-2840-11-19",

language = "English",

volume = "11",

pages = "19",

journal = "Cardiovascular Diabetology",

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TY - JOUR

T1 - NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

AU - Reinhard, Henrik

AU - Hansen, Peter R

AU - Wiinberg, Niels

AU - Kjær, Andreas

AU - Petersen, Claus L

AU - Winther, Kaj

AU - Parving, Hans-Henrik

AU - Rossing, Peter

AU - Jacobsen, Peter K

PY - 2012

Y1 - 2012

N2 - Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients with microalbuminuria receiving intensive multifactorial treatment.

AB - Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients with microalbuminuria receiving intensive multifactorial treatment.

KW - Aged

KW - Albuminuria

KW - Asymptomatic Diseases

KW - Biological Markers

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Cross-Sectional Studies

KW - Denmark

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - Echocardiography, Doppler

KW - Female

KW - Heart Atria

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Myocardial Perfusion Imaging

KW - Natriuretic Peptide, Brain

KW - Odds Ratio

KW - Peptide Fragments

KW - Predictive Value of Tests

KW - Risk Assessment

KW - Risk Factors

KW - Tomography, X-Ray Computed

KW - Ventricular Dysfunction, Left

UR - https://www.scopus.com/pages/publications/84857671892

U2 - 10.1186/1475-2840-11-19

DO - 10.1186/1475-2840-11-19

M3 - Journal article

C2 - 22390472

SN - 1475-2840

VL - 11

SP - 19

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -

NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

Abstract

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