TY - JOUR
T1 - Novel treatment strategies in cardiogenic shock
T2 - an update on ongoing clinical trials
AU - Padilla-Lopez, Mireia
AU - Manicone, Francesca
AU - Holle, Sarah L.D.
AU - Wenzl, Florian A.
AU - Kimmoun, Antoine
AU - Mebazaa, Alexandre
AU - Sionis, Alessandro
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
PY - 2026/12
Y1 - 2026/12
N2 - The identification and management of cardiogenic shock remain significant clinical challenges, as evidenced by persistently high mortality rates and the absence of standardized therapeutic strategies. This article provides a comprehensive overview of ongoing clinical trials in the treatment of cardiogenic shock, organized into three principal approaches aimed at improving patient outcomes: novel pharmacological therapies, optimized use of mechanical circulatory support, and advanced hemodynamic monitoring strategies. By synthesizing the available evidence, we highlight current research directions and discuss how emerging data may inform future clinical practice.
AB - The identification and management of cardiogenic shock remain significant clinical challenges, as evidenced by persistently high mortality rates and the absence of standardized therapeutic strategies. This article provides a comprehensive overview of ongoing clinical trials in the treatment of cardiogenic shock, organized into three principal approaches aimed at improving patient outcomes: novel pharmacological therapies, optimized use of mechanical circulatory support, and advanced hemodynamic monitoring strategies. By synthesizing the available evidence, we highlight current research directions and discuss how emerging data may inform future clinical practice.
KW - Cardiogenic shock
KW - Clinical trials
KW - Heart failure
KW - Mechanical circulatory support
KW - Myocardial infarction
UR - https://www.scopus.com/pages/publications/105038161562
U2 - 10.1007/s10741-026-10637-z
DO - 10.1007/s10741-026-10637-z
M3 - Review
C2 - 42095992
AN - SCOPUS:105038161562
SN - 1382-4147
VL - 31
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 1
M1 - 64
ER -