Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Diana Julie Leeming; M A Karsdal; I Byrjalsen; C Christiansen; F Bendtsen; J Trebicka; M J Nielsen; Søren Møller; A Krag

doi:10.1111/apt.12484

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Diana Julie Leeming, M A Karsdal, I Byrjalsen, C Christiansen, F Bendtsen, J Trebicka, M J Nielsen, Søren Møller, A Krag

88 Citationer (Scopus)

Abstract

The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

Originalsprog	Engelsk
Tidsskrift	Alimentary Pharmacology and Therapeutics
Vol/bind	38
Udgave nummer	9
Sider (fra-til)	1086-96
Antal sider	11
ISSN	0269-2813
DOI	https://doi.org/10.1111/apt.12484
Status	Udgivet - nov. 2013

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10.1111/apt.12484

Citationsformater

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title = "Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension",

abstract = "The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.",

author = "Leeming, {Diana Julie} and Karsdal, {M A} and I Byrjalsen and C Christiansen and F Bendtsen and J Trebicka and Nielsen, {M J} and S{\o}ren M{\o}ller and A Krag",

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AU - Leeming, Diana Julie

AU - Karsdal, M A

AU - Byrjalsen, I

AU - Christiansen, C

AU - Bendtsen, F

AU - Trebicka, J

AU - Nielsen, M J

AU - Møller, Søren

AU - Krag, A

PY - 2013/11

Y1 - 2013/11

N2 - The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

AB - The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

U2 - 10.1111/apt.12484

DO - 10.1111/apt.12484

M3 - Journal article

C2 - 24099470

SN - 0269-2813

VL - 38

SP - 1086

EP - 1096

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 9

ER -

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Abstract

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