Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Diana Julie Leeming, M A Karsdal, I Byrjalsen, C Christiansen, F Bendtsen, J Trebicka, M J Nielsen, Søren Møller, A Krag

85 Citationer (Scopus)

Abstract

The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.
OriginalsprogEngelsk
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind38
Udgave nummer9
Sider (fra-til)1086-96
Antal sider11
ISSN0269-2813
DOI
StatusUdgivet - nov. 2013

Fingeraftryk

Dyk ned i forskningsemnerne om 'Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension'. Sammen danner de et unikt fingeraftryk.

Citationsformater