Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Suzanne Vogelezang
  • Jonathan P Bradfield
  • Tarunveer S Ahluwalia
  • John A Curtin
  • Timo A Lakka
  • Niels Grarup
  • Markus Scholz
  • Peter J van der Most
  • Claire Monnereau
  • Evie Stergiakouli
  • Anni Heiskala
  • Momoko Horikoshi
  • Iryna O Fedko
  • Natalia Vilor-Tejedor
  • Diana L Cousminer
  • Marie Standl
  • Carol A Wang
  • Jorma Viikari
  • Frank Geller
  • Carmen Íñiguez
  • Niina Pitkänen
  • Alessandra Chesi
  • Jonas Bacelis
  • Loic Yengo
  • Maties Torrent
  • Ioanna Ntalla
  • Øyvind Helgeland
  • Saskia Selzam
  • Judith M Vonk
  • Mohammed H Zafarmand
  • Barbara Heude
  • Ismaa Sadaf Farooqi
  • Akram Alyass
  • Robin N Beaumont
  • Christian T Have
  • Peter Rzehak
  • Jose Ramon Bilbao
  • Theresia M Schnurr
  • Inês Barroso
  • Klaus Bønnelykke
  • Bo Chawes
  • Torben Hansen
  • Kim F Michaelsen
  • Camilla S Morgen
  • Tenna R H Nielsen
  • Jakob Stokholm
  • Rebecca K Vinding
  • Thorkild I A Sørensen
  • Jens-Christian Holm
  • Hans Bisgaard
  • Early Growth Genetics Consortium
Vis graf over relationer

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R g ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

OriginalsprogEngelsk
Artikelnummere1008718
TidsskriftP L o S Genetics
Vol/bind16
Udgave nummer10
Sider (fra-til)e1008718
ISSN1553-7390
DOI
StatusUdgivet - 12 okt. 2020

ID: 61114515