Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age

Dorthe Lisbeth Jeppesen, Annette Kjær Ersbøll, Tine Ursula Hoppe, Susanne Dam Nielsen, Niels Henrik Valerius

Abstrakt

Objective. To evaluate the immune function in HIV-exposed uninfected (HIV-EU) infants fed human donor milk. Methods. Ultrasound-obtained thymic index (Ti), T-lymphocyte subsets, and the number of infections were examined from birth to 18 months of age in 18 HIV-EU infants. The infants were compared to a cohort of 47 term, HIV-unexposed breastfed or formula-fed infants. Results. The thymic size at 12 months of age was not significantly different between the HIV-EU group and the control infants (P = 0.56). At 4 months of age, the HIV-EU infants had significantly fewer infections than the control infants (P
OriginalsprogEngelsk
TidsskriftInternational Journal of Pediatrics
Vol/bind2013
Sider (fra-til)373790
ISSN1687-9740
DOI
StatusUdgivet - 2013

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