TY - JOUR
T1 - Normal regional tissue oxygen saturation in neonates
T2 - a systematic qualitative review
AU - Bruckner, Marlies
AU - Wolfsberger, Christina H
AU - Dempsey, Eugene M
AU - Liem, Kian D
AU - Lemmers, Petra
AU - Alderliesten, Thomas
AU - Alarcon, Ana
AU - Mintzer, Jonathan
AU - de Boode, Willem P
AU - Schmölzer, Georg M
AU - Pichler, Gerhard
AU - ESPR Special Interest Group “Near InfraRed Spectroscopy” (NIRS)
A2 - Hansen, Mathias Lühr
N1 - © 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: The aim of this systematic qualitative review was to give an overview of reference ranges defined as normal values or centile charts of regional tissue oxygen saturation measured by near-infrared spectroscopy (NIRS) in term and preterm neonates.METHODS: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed. Additional articles were identified by manual search of cited references. Only human studies in neonates were included.RESULTS: Nineteen studies were identified. Eight described regional tissue oxygen saturation during fetal-to-neonatal transition, six during the first 3 days after birth, four during the first 7 days after birth, and one during the first 8 weeks after birth. Nine described regional tissue oxygen saturation in term, nine in preterm neonates, and one in both. Eight studies published centile charts for cerebral regional tissue oxygen saturation, and only five included large cohorts of infants. Eleven studies described normal values for cerebral, muscle, renal, and abdominal regional tissue oxygen saturation, the majority with small sample sizes. Four studies of good methodological quality were identified describing centile charts of cerebral regional tissue oxygen saturation.CONCLUSIONS: In clinical settings, quality centile charts are available and should be the preferred method when using NIRS monitoring.IMPACT: Near-infrared spectroscopy (NIRS) enables a bed-side non-invasive continuous monitoring of tissue oxygenation. When using NIRS monitoring in a clinical setting, centile charts with good quality are available and should be preferred to normal values. High-quality reference ranges of regional tissue oxygenation in term and preterm born neonates are an important step toward routine clinical application of NIRS.
AB - BACKGROUND: The aim of this systematic qualitative review was to give an overview of reference ranges defined as normal values or centile charts of regional tissue oxygen saturation measured by near-infrared spectroscopy (NIRS) in term and preterm neonates.METHODS: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed. Additional articles were identified by manual search of cited references. Only human studies in neonates were included.RESULTS: Nineteen studies were identified. Eight described regional tissue oxygen saturation during fetal-to-neonatal transition, six during the first 3 days after birth, four during the first 7 days after birth, and one during the first 8 weeks after birth. Nine described regional tissue oxygen saturation in term, nine in preterm neonates, and one in both. Eight studies published centile charts for cerebral regional tissue oxygen saturation, and only five included large cohorts of infants. Eleven studies described normal values for cerebral, muscle, renal, and abdominal regional tissue oxygen saturation, the majority with small sample sizes. Four studies of good methodological quality were identified describing centile charts of cerebral regional tissue oxygen saturation.CONCLUSIONS: In clinical settings, quality centile charts are available and should be the preferred method when using NIRS monitoring.IMPACT: Near-infrared spectroscopy (NIRS) enables a bed-side non-invasive continuous monitoring of tissue oxygenation. When using NIRS monitoring in a clinical setting, centile charts with good quality are available and should be preferred to normal values. High-quality reference ranges of regional tissue oxygenation in term and preterm born neonates are an important step toward routine clinical application of NIRS.
UR - http://www.scopus.com/inward/record.url?scp=85117317596&partnerID=8YFLogxK
U2 - 10.1038/s41390-021-01786-y
DO - 10.1038/s41390-021-01786-y
M3 - Journal article
C2 - 34667270
SN - 0031-3998
SP - 1
EP - 12
JO - Pediatric Research
JF - Pediatric Research
ER -