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Region Hovedstaden - en del af Københavns Universitetshospital
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Normal P50 Gating in Children with Autism, Yet Attenuated P50 Amplitude in the Asperger Subcategory

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  1. Do cognitive deficits persist into adolescence in autism?

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  2. Auditory processing in autism spectrum disorder: Mismatch negativity deficits

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  3. Exploring 'The autisms' at a cognitive level

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  4. Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children

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Vis graf over relationer

Autism spectrum disorders (ASD) and schizophrenia are separate disorders, but there is evidence of conversion or comorbid overlap. The objective of this paper was to explore whether deficits in sensory gating, as seen in some schizophrenia patients, can also be found in a group of ASD children compared to neurotypically developed children. An additional aim was to investigate the possibility of subdividing our ASD sample based on these gating deficits. In a case-control design, we assessed gating of the P50 and N100 amplitude in 31 ASD children and 39 healthy matched controls (8-12 years) and screened for differences between groups and within the ASD group. We did not find disturbances in auditory P50 and N100 filtering in the group of ASD children as a whole, nor did we find abnormal P50 and N100 amplitudes. However, the P50 amplitude to the conditioning stimulus was significantly reduced in the Asperger subgroup compared to healthy controls. In contrast to what is usually reported for patients with schizophrenia, we found no evidence for sensory gating deficits in our group of ASD children taken as a whole. However, reduced P50 amplitude to conditioning stimuli was found in the Asperger group, which is similar to what has been described in some studies in schizophrenia patients. There was a positive correlation between the P50 amplitude of the conditioning stimuli and anxiety score in the pervasive developmental disorder not otherwise specified group, which indicates a relation between anxiety and sensory registration in this group. Autism Res 2015. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

OriginalsprogEngelsk
Artikelnummer4
TidsskriftAutism Research
Vol/bind8
Sider (fra-til)371-8
Antal sider8
ISSN1939-3792
DOI
StatusUdgivet - 20 aug. 2015

ID: 45024145