Noninvasive fetal blood group antigen genotyping

Frederik Banch Clausen; C. Ellen van der Schoot

doi:10.2450/BloodTransfus.712

Noninvasive fetal blood group antigen genotyping

Frederik Banch Clausen^*, C. Ellen van der Schoot

^*Corresponding author af dette arbejde

Afdeling for Klinisk Immunologi DIA

6 Citationer (Scopus)

Abstract

Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.

Originalsprog	Engelsk
Tidsskrift	Blood Transfusion
Vol/bind	23
Udgave nummer	2
Sider (fra-til)	101-108
Antal sider	8
ISSN	1723-2007
DOI	https://doi.org/10.2450/BloodTransfus.712
Status	Udgivet - mar. 2025

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10.2450/BloodTransfus.712Licens: CC BY-NC-ND

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abstract = "Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.",

keywords = "blood group genotyping, cell-free DNA, HDFN, immunization, prophylaxis",

author = "Clausen, {Frederik Banch} and {van der Schoot}, {C. Ellen}",

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year = "2025",

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doi = "10.2450/BloodTransfus.712",

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AU - Clausen, Frederik Banch

AU - van der Schoot, C. Ellen

N1 - Publisher Copyright: © SIMTIPRO Srl.

PY - 2025/3

Y1 - 2025/3

N2 - Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.

AB - Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.

KW - blood group genotyping

KW - cell-free DNA

KW - HDFN

KW - immunization

KW - prophylaxis

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VL - 23

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JO - Blood Transfusion

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ER -

Noninvasive fetal blood group antigen genotyping

Abstract

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