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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Noninvasive Antenatal Screening for Fetal RHD in RhD Negative Women to Guide Targeted Anti-D Prophylaxis

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Vis graf over relationer

RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis.Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis.

OriginalsprogEngelsk
TidsskriftMethods in molecular biology
Vol/bind1885
Sider (fra-til)347-359
Antal sider13
ISSN1064-3745
DOI
StatusUdgivet - 2019

ID: 57849819