TY - JOUR
T1 - Non-invasive [15O]H2O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan
AU - Bach, Mathias Jacobsen
AU - Larsen, Mia E
AU - Kellberg, Amanda O
AU - Henriksen, Alexander C
AU - Fuglsang, Stefan
AU - Rasmussen, Inge Lise
AU - Lonsdale, Markus Nowak
AU - Lubberink, Mark
AU - Marner, Lisbeth
PY - 2025/6
Y1 - 2025/6
N2 - Obtaining the arterial input function (AIF) is essential for quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET. However, arterial blood sampling is invasive and complicates the scanning procedure. We propose a new non-invasive dual scan technique with an image derived input function (IDIF) from an additional heart scan. Six patients and two healthy subjects underwent [15O]H2O PET imaging of 1) heart and brain during baseline, and 2) heart and brain after infusion of acetazolamide. The IDIF was extracted from the left ventricle of the heart and compared to the AIF. The rCBF was compared for six bilateral cortical regions. AIFs and IDIFs showed strong agreement. rCBF with AIF and IDIF showed strong correlation for both baseline rCBF (R2 = 0.99, slope = 0.89 CI: [0.87; 0.91], p < 0.0001) and acetazolamide rCBF (R2 = 0.98, slope = 0.93, CI:[0.90;0.97], p < 0.0001) but showed a positive bias of 0.047 mL/(g·min) [-0.025; +0.119] for baseline and 0.024 [-1.04, +1.53] mL/(g·min) for acetazolamide. In conclusion, the invasive arterial cannulation can be replaced by an additional scan of the heart with a minor bias of rCBF estimation. The method is applicable to all scanner systems.
AB - Obtaining the arterial input function (AIF) is essential for quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET. However, arterial blood sampling is invasive and complicates the scanning procedure. We propose a new non-invasive dual scan technique with an image derived input function (IDIF) from an additional heart scan. Six patients and two healthy subjects underwent [15O]H2O PET imaging of 1) heart and brain during baseline, and 2) heart and brain after infusion of acetazolamide. The IDIF was extracted from the left ventricle of the heart and compared to the AIF. The rCBF was compared for six bilateral cortical regions. AIFs and IDIFs showed strong agreement. rCBF with AIF and IDIF showed strong correlation for both baseline rCBF (R2 = 0.99, slope = 0.89 CI: [0.87; 0.91], p < 0.0001) and acetazolamide rCBF (R2 = 0.98, slope = 0.93, CI:[0.90;0.97], p < 0.0001) but showed a positive bias of 0.047 mL/(g·min) [-0.025; +0.119] for baseline and 0.024 [-1.04, +1.53] mL/(g·min) for acetazolamide. In conclusion, the invasive arterial cannulation can be replaced by an additional scan of the heart with a minor bias of rCBF estimation. The method is applicable to all scanner systems.
KW - Humans
KW - Cerebrovascular Circulation/physiology
KW - Male
KW - Positron-Emission Tomography/methods
KW - Female
KW - Middle Aged
KW - Oxygen Radioisotopes
KW - Acetazolamide
KW - Adult
KW - Brain/diagnostic imaging
KW - Heart/diagnostic imaging
KW - Aged
UR - http://www.scopus.com/inward/record.url?scp=85215439444&partnerID=8YFLogxK
U2 - 10.1177/0271678X251313743
DO - 10.1177/0271678X251313743
M3 - Journal article
C2 - 39829334
SN - 0271-678X
VL - 45
SP - 1144
EP - 1152
JO - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
IS - 6
ER -