NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population

S Yazdanyar; B G Nordestgaard

doi:10.1111/j.1365-2796.2010.02232.x

NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population

8 Citationer (Scopus)

Abstract

The NOD2/CARD15 gene is involved in the innate immune response, and thus in inflammation. Three polymorphisms in this gene (Arg702Trp rs2066844, Gly908Arg rs2066845 and Leu1007fsinsC rs5743293) have been associated with increased risk of the inflammatory bowel disease, the Crohn's disease. We tested whether these polymorphisms are also associated with increased risk of cardiovascular disease and cancer, in which the innate immune system and inflammation may influence pathogenesis.

Originalsprog	Engelsk
Tidsskrift	The Egyptian Journal of Internal Medicine
Vol/bind	268
Udgave nummer	2
Sider (fra-til)	162-70
Antal sider	9
ISSN	1110-7782
DOI	https://doi.org/10.1111/j.1365-2796.2010.02232.x
Status	Udgivet - aug. 2010

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10.1111/j.1365-2796.2010.02232.x

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title = "NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population",

abstract = "The NOD2/CARD15 gene is involved in the innate immune response, and thus in inflammation. Three polymorphisms in this gene (Arg702Trp rs2066844, Gly908Arg rs2066845 and Leu1007fsinsC rs5743293) have been associated with increased risk of the inflammatory bowel disease, the Crohn's disease. We tested whether these polymorphisms are also associated with increased risk of cardiovascular disease and cancer, in which the innate immune system and inflammation may influence pathogenesis.",

keywords = "Adult, Cardiovascular Diseases, Denmark, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Neoplasms, Nod2 Signaling Adaptor Protein, Polymorphism, Single Nucleotide",

author = "S Yazdanyar and Nordestgaard, {B G}",

year = "2010",

month = aug,

doi = "10.1111/j.1365-2796.2010.02232.x",

language = "English",

volume = "268",

pages = "162--70",

journal = "The Egyptian Journal of Internal Medicine",

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TY - JOUR

T1 - NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population

AU - Yazdanyar, S

AU - Nordestgaard, B G

PY - 2010/8

Y1 - 2010/8

N2 - The NOD2/CARD15 gene is involved in the innate immune response, and thus in inflammation. Three polymorphisms in this gene (Arg702Trp rs2066844, Gly908Arg rs2066845 and Leu1007fsinsC rs5743293) have been associated with increased risk of the inflammatory bowel disease, the Crohn's disease. We tested whether these polymorphisms are also associated with increased risk of cardiovascular disease and cancer, in which the innate immune system and inflammation may influence pathogenesis.

AB - The NOD2/CARD15 gene is involved in the innate immune response, and thus in inflammation. Three polymorphisms in this gene (Arg702Trp rs2066844, Gly908Arg rs2066845 and Leu1007fsinsC rs5743293) have been associated with increased risk of the inflammatory bowel disease, the Crohn's disease. We tested whether these polymorphisms are also associated with increased risk of cardiovascular disease and cancer, in which the innate immune system and inflammation may influence pathogenesis.

KW - Adult

KW - Cardiovascular Diseases

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Nod2 Signaling Adaptor Protein

KW - Polymorphism, Single Nucleotide

U2 - 10.1111/j.1365-2796.2010.02232.x

DO - 10.1111/j.1365-2796.2010.02232.x

M3 - Journal article

C2 - 20412372

SN - 1110-7782

VL - 268

SP - 162

EP - 170

JO - The Egyptian Journal of Internal Medicine

JF - The Egyptian Journal of Internal Medicine

IS - 2

ER -

NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population

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