No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration

Inger Marie Jensen Hansen, Amir Emamifar, Rikke Asmussen Andreasen, Steen Antonsen

Abstract

Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision. The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification. This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP= 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from
OriginalsprogEngelsk
TidsskriftMedicine (United States)
Vol/bind96
Udgave nummer1
ISSN0025-7974
DOI
StatusUdgivet - jan. 2017
Udgivet eksterntJa

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