No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration

Inger Marie Jensen Hansen, Amir Emamifar, Rikke Asmussen Andreasen, Steen Antonsen

9 Citationer (Scopus)

Abstract

Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision. The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification. This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP= 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from
OriginalsprogEngelsk
TidsskriftMedicine (United States)
Vol/bind96
Udgave nummer1
ISSN0025-7974
DOI
StatusUdgivet - jan. 2017
Udgivet eksterntJa

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