Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

No evidence that genetic variation in the myeloid-derived suppressor cell pathway influences ovarian cancer survival

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Metabolic Pathway Analysis and Effectiveness of Tamoxifen in Danish Breast Cancer Patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk of Anal Cancer Following Benign Anal Disease and Anal Cancer Precursor Lesions: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A Cohort Study of Breast Cancer Risk after 20 Years of Follow-Up of Women Treated with Fertility Drugs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. MicroRNA Biomarkers in IBD-Differential Diagnosis and Prediction of Colitis-Associated Cancer

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Ovarian removal at or after benign hysterectomy and breast cancer: a nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Use of nonaspirin nonsteroidal anti-inflammatory drugs and risk of head and neck cancer: A nationwide case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lara E Sucheston-Campbell
  • Rikki Cannioto
  • Alyssa I Clay
  • John Lewis Etter
  • Kevin H Eng
  • Song Liu
  • Sebastiano Battaglia
  • Qiang Hu
  • J Brian Szender
  • Albina Minlikeeva
  • Janine Joseph
  • Paul Mayor
  • Scott I Abrams
  • Brahm Segal
  • Paul K Wallace
  • Kah Teong Soh
  • Emese Z Zsiros
  • Hoda Anton-Culver
  • Elisa V Bandera
  • Matthias W Beckmann
  • Andrew Berchuck
  • Line Bjørge
  • Amanda Bruegl
  • Ian G Campbell
  • Shawn Patrice Campbell
  • Georgia Chenevix-Trench
  • Daniel Cramer
  • Agnieszka Dansonka-Mieszkowska
  • Fanny Dao
  • Brenda Diergaarde
  • Thilo Doerk
  • Jennifer A Doherty
  • Andreas du Bois
  • Diana Eccles
  • Svend Aage Engelholm
  • Peter A Fasching
  • Simon A Gayther
  • Aleksandra Gentry-Maharaj
  • Rosalind M Glasspool
  • Marc T Goodman
  • Jacek Gronwald
  • Philipp Harter
  • Alexander Hein
  • Florian Heitz
  • Peter Hillemmanns
  • Claus Hogdall
  • Estrid Vilma Solyom Høgdall
  • Tomasz Huzarski
  • Allan Jensen
  • Sharon E Johnatty
  • Audrey Jung
  • Beth Karlan
  • Rüdiger Klapdor
  • Tomasz Kluz
  • Bozena Konopka
  • Susanne Krüger Kjær
  • Jolanta Kupryjanczyk
  • Diether Lambrechts
  • Jenny Lester
  • Jan Lubiński
  • Douglas A Levine
  • Lene Lundvall
  • Valerie McGuire
  • Iain A McNeish
  • Usha Menon
  • Francesmary Modugno
  • Roberta B Ness
  • Sandra Orsulic
  • James Paul
  • Celeste Leigh Pearce
  • Tanja Pejovic
  • Paul Pharoah
  • Susan J Ramus
  • Joseph Rothstein
  • Mary Anne Rossing
  • Matthias Rübner
  • Joellen M Schildkraut
  • Barbara Schmalfeldt
  • Ira Schwaab
  • Nadeem Siddiqui
  • Weiva Sieh
  • Piotr Sobiczewski
  • Honglin Song
  • Kathryn L Terry
  • Els Van Nieuwenhuysen
  • Adriaan Vanderstichele
  • Ignace Vergote
  • Christine S Walsh
  • Penelope M Webb
  • Nicolas Wentzensen
  • Alice S Whittemore
  • Anna H Wu
  • Argyrios Ziogas
  • Kunle Odunsi
  • Jenny Chang-Claude
  • Ellen L Goode
  • Kirsten B Moysich
Vis graf over relationer

BACKGROUND: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immune suppressive/pro-tumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be one prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.

METHODS: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association study (VEGAS) and the Admixture Likelihood method (AML), were used to test gene and pathway associations with survival.

RESULTS: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (p<3.5 x 10-5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.

CONCLUSIONS: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.

IMPACT: Common inherited variation in genes relevant to MDSCs were not associated with survival in women diagnosed with invasive EOC.

TidsskriftCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Udgave nummer3
Sider (fra-til)420-424
StatusUdgivet - 2017

ID: 49467880