No effect of Osteoset, a bone graft substitute, on bone healing in humans: a prospective randomized double-blind study

Juozas Petruskevicius, Mette Strange Nielsen, Søren Kaalund, Preben R Knudsen, Søren Overgaard

44 Citationer (Scopus)

Abstract

We studied the effects of a newly marketed bone substitute, Osteoset, on bone healing in a tibial defect in humans. 20 patients undergoing an ACL (anterior cruciate ligament) reconstruction with bone-patella tendon-bone graft were block-randomized into 2 groups of 10 each. In the treatment group, the tibial defect was filled manually with Osteoset pellets, in the control group the defect was left empty. CTs of the defect were taken on the first day after the operation, 6 weeks, 3 and 6 months postoperatively. We found about the same amount of bone in the defect in the Osteoset and control groups after 6 weeks, 3, and 6 months. In the control group, but not in the Osteoset group, the bone volume increased from 6 weeks to 3 months. The Osteoset pellets were almost resorbed after 6 weeks.
OriginalsprogEngelsk
TidsskriftActa Orthopaedica
Vol/bind73
Udgave nummer5
Sider (fra-til)575-8
Antal sider4
ISSN1745-3674
DOI
StatusUdgivet - 2002
Udgivet eksterntJa

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