No effect of oral contraceptives on the metabolism of levetiracetam

Anne Sabers; Jacob Christensen

doi:10.1016/j.eplepsyres.2011.04.001

No effect of oral contraceptives on the metabolism of levetiracetam

Anne Sabers
, Jacob Christensen

Afdeling for Hjerne- og Nervesygdomme NEU

11 Citationer (Scopus)

Abstract

The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

Originalsprog	Engelsk
Tidsskrift	Epilepsy Research
Vol/bind	95
Udgave nummer	3
Sider (fra-til)	277-9
Antal sider	3
ISSN	0920-1211
DOI	https://doi.org/10.1016/j.eplepsyres.2011.04.001
Status	Udgivet - 2011

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10.1016/j.eplepsyres.2011.04.001

Citationsformater

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title = "No effect of oral contraceptives on the metabolism of levetiracetam",

abstract = "The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.",

keywords = "Adolescent, Adult, Anticonvulsants, Contraceptives, Oral, Dose-Response Relationship, Drug, Epilepsy, Female, Humans, Middle Aged, Piracetam, Pregnancy, Young Adult",

author = "Anne Sabers and Jacob Christensen",

year = "2011",

doi = "10.1016/j.eplepsyres.2011.04.001",

language = "English",

volume = "95",

pages = "277--9",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier BV",

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T1 - No effect of oral contraceptives on the metabolism of levetiracetam

AU - Sabers, Anne

AU - Christensen, Jacob

PY - 2011

Y1 - 2011

N2 - The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

AB - The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

KW - Adolescent

KW - Adult

KW - Anticonvulsants

KW - Contraceptives, Oral

KW - Dose-Response Relationship, Drug

KW - Epilepsy

KW - Female

KW - Humans

KW - Middle Aged

KW - Piracetam

KW - Pregnancy

KW - Young Adult

U2 - 10.1016/j.eplepsyres.2011.04.001

DO - 10.1016/j.eplepsyres.2011.04.001

M3 - Journal article

C2 - 21549563

SN - 0920-1211

VL - 95

SP - 277

EP - 279

JO - Epilepsy Research

JF - Epilepsy Research

IS - 3

ER -

No effect of oral contraceptives on the metabolism of levetiracetam

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