No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT

Gerda Thomsen; Gitte Moos Knudsen; Peter S Jensen; Morten Ziebell; Klaus K Holst; Susanne Asenbaum; Jan Booij; Jacques Darcourt; John C Dickson; Ozlem L Kapucu; Flavio Nobili; Osama Sabri; Terez Sera; Klaus Tatsch; Livia Tossici-Bolt; Koen Van Laere; Thierry Vander Borght; Andrea Varrone; Marco Pagani; Lars Hageman Pinborg

doi:10.1186/2191-219X-3-39

No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT

Gerda Thomsen, Gitte Moos Knudsen, Peter S Jensen, Morten Ziebell, Klaus K Holst, Susanne Asenbaum, Jan Booij, Jacques Darcourt, John C Dickson, Ozlem L Kapucu, Flavio Nobili, Osama Sabri, Terez Sera, Klaus Tatsch, Livia Tossici-Bolt, Koen Van Laere, Thierry Vander Borght, Andrea Varrone, Marco Pagani, Lars Hageman Pinborg

20 Citationer (Scopus)

Abstract

Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers.

Originalsprog	Engelsk
Tidsskrift	EJNMMI Research
Vol/bind	3
Udgave nummer	1
Sider (fra-til)	39
ISSN	2191-219X
DOI	https://doi.org/10.1186/2191-219X-3-39
Status	Udgivet - 2013

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10.1186/2191-219X-3-39

Citationsformater

Thomsen, G., Knudsen, G. M., Jensen, P. S., Ziebell, M., Holst, K. K., Asenbaum, S., Booij, J., Darcourt, J., Dickson, J. C., Kapucu, O. L., Nobili, F., Sabri, O., Sera, T., Tatsch, K., Tossici-Bolt, L., Laere, K. V., Borght, T. V., Varrone, A., Pagani, M., & Pinborg, L. H. (2013). No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. EJNMMI Research, 3(1), 39. https://doi.org/10.1186/2191-219X-3-39

Thomsen, G , Knudsen, GM , Jensen, PS, Ziebell, M, Holst, KK, Asenbaum, S, Booij, J, Darcourt, J, Dickson, JC, Kapucu, OL, Nobili, F, Sabri, O, Sera, T, Tatsch, K, Tossici-Bolt, L, Laere, KV, Borght, TV, Varrone, A, Pagani, M & Pinborg, LH 2013, 'No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT', EJNMMI Research, bind 3, nr. 1, s. 39. https://doi.org/10.1186/2191-219X-3-39

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title = "No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT",

abstract = "Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers.",

author = "Gerda Thomsen and Knudsen, {Gitte Moos} and Jensen, {Peter S} and Morten Ziebell and Holst, {Klaus K} and Susanne Asenbaum and Jan Booij and Jacques Darcourt and Dickson, {John C} and Kapucu, {Ozlem L} and Flavio Nobili and Osama Sabri and Terez Sera and Klaus Tatsch and Livia Tossici-Bolt and Laere, {Koen Van} and Borght, {Thierry Vander} and Andrea Varrone and Marco Pagani and Pinborg, {Lars Hageman}",

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doi = "10.1186/2191-219X-3-39",

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T1 - No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT

AU - Thomsen, Gerda

AU - Knudsen, Gitte Moos

AU - Jensen, Peter S

AU - Ziebell, Morten

AU - Holst, Klaus K

AU - Asenbaum, Susanne

AU - Booij, Jan

AU - Darcourt, Jacques

AU - Dickson, John C

AU - Kapucu, Ozlem L

AU - Nobili, Flavio

AU - Sabri, Osama

AU - Sera, Terez

AU - Tatsch, Klaus

AU - Tossici-Bolt, Livia

AU - Laere, Koen Van

AU - Borght, Thierry Vander

AU - Varrone, Andrea

AU - Pagani, Marco

AU - Pinborg, Lars Hageman

PY - 2013

Y1 - 2013

N2 - Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers.

AB - Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers.

U2 - 10.1186/2191-219X-3-39

DO - 10.1186/2191-219X-3-39

M3 - Journal article

C2 - 23688063

SN - 2191-219X

VL - 3

SP - 39

JO - EJNMMI Research

JF - EJNMMI Research

IS - 1

ER -

No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT

Abstract

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