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No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

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Vis graf over relationer
Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.
OriginalsprogEngelsk
TidsskriftObesity (Silver Spring, Md.)
Vol/bind21
Udgave nummer9
Sider (fra-til)1803-6
Antal sider4
ISSN1930-7381
DOI
StatusUdgivet - sep. 2013

ID: 42575465