No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

G Thomsen; M Ziebell; Peter Steen Jensen; Sofi da Cunha-Bang; G M Knudsen; L H Pinborg

doi:10.1002/oby.20225

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

G Thomsen, M Ziebell, Peter Steen Jensen, Sofi da Cunha-Bang, G M Knudsen, L H Pinborg

35 Citationer (Scopus)

Abstract

Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.

Originalsprog	Engelsk
Tidsskrift	Obesity (Silver Spring, Md.)
Vol/bind	21
Udgave nummer	9
Sider (fra-til)	1803-6
Antal sider	4
ISSN	1930-7381
DOI	https://doi.org/10.1002/oby.20225
Status	Udgivet - sep. 2013

Adgang til dokumentet

10.1002/oby.20225

Citationsformater

@article{cccfb484f76d401c8096223111b478c1,

title = "No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I",

abstract = "Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.",

author = "G Thomsen and M Ziebell and Jensen, {Peter Steen} and {da Cunha-Bang}, Sofi and Knudsen, {G M} and Pinborg, {L H}",

note = "Copyright {\textcopyright} 2012 The Obesity Society.",

year = "2013",

month = sep,

doi = "10.1002/oby.20225",

language = "English",

volume = "21",

pages = "1803--6",

journal = "Obesity (Silver Spring, Md.)",

issn = "1930-7381",

publisher = "John Wiley and Sons Inc.",

number = "9",

}

TY - JOUR

T1 - No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

AU - Thomsen, G

AU - Ziebell, M

AU - Jensen, Peter Steen

AU - da Cunha-Bang, Sofi

AU - Knudsen, G M

AU - Pinborg, L H

PY - 2013/9

Y1 - 2013/9

N2 - Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.

AB - Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.

U2 - 10.1002/oby.20225

DO - 10.1002/oby.20225

M3 - Journal article

C2 - 23696269

SN - 1930-7381

VL - 21

SP - 1803

EP - 1806

JO - Obesity (Silver Spring, Md.)

JF - Obesity (Silver Spring, Md.)

IS - 9

ER -

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater