No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

Anette Marianne Prior Gjesing; Thomas Hempel Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen; Niels V Olsen

doi:10.1371/journal.pone.0007206

No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

Anette Marianne Prior Gjesing
, Thomas Hempel Sparsø
, Knut Borch-Johnsen
, Torben Jørgensen
, Oluf Pedersen
, Torben Hansen
, Niels V Olsen

Afdeling for Hjerne- og Nervesygdomme NEU

16 Citationer (Scopus)

Abstract

Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	4
Udgave nummer	9
Sider (fra-til)	e7206
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0007206
Status	Udgivet - 1 jan. 2009

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10.1371/journal.pone.0007206

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No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes. / Gjesing, Anette Marianne Prior; Sparsø, Thomas Hempel; Borch-Johnsen, Knut et al.
I: P L o S One, Bind 4, Nr. 9, 01.01.2009, s. e7206.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.",

author = "Gjesing, \{Anette Marianne Prior\} and Spars{\o}, \{Thomas Hempel\} and Knut Borch-Johnsen and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen and Olsen, \{Niels V\}",

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AU - Gjesing, Anette Marianne Prior

AU - Sparsø, Thomas Hempel

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Olsen, Niels V

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.

AB - Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.

U2 - 10.1371/journal.pone.0007206

DO - 10.1371/journal.pone.0007206

M3 - Journal article

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ER -

No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

Abstract

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