No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

Anette Marianne Prior Gjesing, Thomas Hempel Sparsø, Knut Borch-Johnsen, Torben Jørgensen, Oluf Pedersen, Torben Hansen, Niels V Olsen

15 Citationer (Scopus)

Abstract

Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind4
Udgave nummer9
Sider (fra-til)e7206
ISSN1932-6203
DOI
StatusUdgivet - 1 jan. 2009

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