Abstract
Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults.
Originalsprog | Engelsk |
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Tidsskrift | P L o S One |
Vol/bind | 4 |
Udgave nummer | 9 |
Sider (fra-til) | e7206 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 1 jan. 2009 |