Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

No association between pseudotumors, high serum metal-ion levels and metal hypersensitivity in large-head metal-on-metal total hip arthroplasty at 5-7-year follow-up

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reliability of standing weight-bearing (0.25T) MR imaging findings and positional changes in the lumbar spine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Navicular bone position determined by positional MRI: a reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. External pneumatic compression device prevents fainting in standing weight-bearing MRI: a cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The alignment of the knee joint in relationship to age and osteoarthritis: The Copenhagen Osteoarthritis Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cost of Treating Skin Problems in Patients with Diabetes who Use Insulin Pumps and/or Glucose Sensors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dupilumab treatment in two patients with severe allergic contact dermatitis caused by sesquiterpene lactones

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Palmar Eczema From Secondary 2-Hydroxyethyl Methacrylate Exposure-The Artificial Nail Grip Sign

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. 'Barrier dysfunction in Atopic newBorns studY' (BABY): protocol of a Danish prospective birth cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Mette Holm Hjorth
  • Maiken Stilling
  • Kjeld Soballe
  • Lars Hans Bolvig
  • Jacob Pontoppidan Thyssen
  • Inger Mechlenburg
  • Stig Storgaard Jakobsen
Vis graf over relationer

OBJECTIVE: The relationship between metal wear debris, pseudotumor formation and metal hypersensitivity is complex and not completely understood. The purpose of this study was to assess the prevalence of pseudotumor formation in a consecutive series of metal-on-metal (MoM) total hip arthroplasty (THA) and to investigate its relationship to serum metal-ion levels and hypersensitivity to metal.

METHODS: Forty-one patients (31 males), mean age 52 (28-68) years, with a total of 49 large-head MoM THA participated in a 5-7-year follow-up study. Patients underwent ultrasonography, serum metal-ion concentrations were measured, metal allergy and atopic dermatitis were evaluated, and the questionnaires of the Oxford Hip Score (OHS), Harris Hip Score (HHS) and the Short-Form Health Survey (SF-36) were completed.

RESULTS: Pseudotumors were found in eight patients, but they were asymptomatic and their serum metal-ion levels were similar to those observed in patients with no pseudotumors (p > 0.36). The capsule-stem distance of mean 8.6 mm (SD 3.82, 95% CI: 5.40-11.79) was wider (p = 0.02) in patients with pseudotumours than in patients without pseudotumors of mean 5.6 mm (SD 2.89, 95% CI: 4.68-6.58). Positive patch test reactions were seen in three patients. Higher serum metal-ion levels of chromium and cobalt were significantly correlated with steeper cup inclination and smaller femoral head sizes, and were associated with female gender (p < 0.04).

CONCLUSION: We found no association between pseudotumor formation, serum metal-ion levels, metal patch test reactivity, and atopic dermatitis. However, clinicians should be aware of asymptomatic pseudotumors, and we advise further exploration into the mechanisms involved in the pathogenesis of pseudotumors.

OriginalsprogEngelsk
TidsskriftSkeletal Radiology
Vol/bind45
Udgave nummer1
Sider (fra-til)115-25
Antal sider11
ISSN0364-2348
DOI
StatusUdgivet - jan. 2016

ID: 49270556