Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{01d14d6805b24ff980131dd53f91421a,
title = "No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma",
abstract = "Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224-6. {\circledC}2017 AACR.",
keywords = "Adipose Tissue/chemistry, Aged, Biomarkers, Tumor/analysis, Female, Humans, Lymphoma, Non-Hodgkin/chemically induced, Male, Middle Aged, Polychlorinated Biphenyls/analysis, Proportional Hazards Models, Prospective Studies",
author = "Nina Roswall and Mette S{\o}rensen and Br{\"a}uner, {Elvira Vaclavik} and Anne Tj{\o}nneland and Ole Raaschou-Nielsen",
note = "{\circledC}2017 American Association for Cancer Research.",
year = "2018",
month = "2",
doi = "10.1158/1055-9965.EPI-17-0937",
language = "English",
volume = "27",
pages = "224--226",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "2",

}

RIS

TY - JOUR

T1 - No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma

AU - Roswall, Nina

AU - Sørensen, Mette

AU - Bräuner, Elvira Vaclavik

AU - Tjønneland, Anne

AU - Raaschou-Nielsen, Ole

N1 - ©2017 American Association for Cancer Research.

PY - 2018/2

Y1 - 2018/2

N2 - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224-6. ©2017 AACR.

AB - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224-6. ©2017 AACR.

KW - Adipose Tissue/chemistry

KW - Aged

KW - Biomarkers, Tumor/analysis

KW - Female

KW - Humans

KW - Lymphoma, Non-Hodgkin/chemically induced

KW - Male

KW - Middle Aged

KW - Polychlorinated Biphenyls/analysis

KW - Proportional Hazards Models

KW - Prospective Studies

U2 - 10.1158/1055-9965.EPI-17-0937

DO - 10.1158/1055-9965.EPI-17-0937

M3 - Journal article

VL - 27

SP - 224

EP - 226

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 2

ER -

ID: 57255785