TY - JOUR
T1 - No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma
AU - Roswall, Nina
AU - Sørensen, Mette
AU - Bräuner, Elvira Vaclavik
AU - Tjønneland, Anne
AU - Raaschou-Nielsen, Ole
N1 - ©2017 American Association for Cancer Research.
PY - 2018/2
Y1 - 2018/2
N2 - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224-6. ©2017 AACR.
AB - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224-6. ©2017 AACR.
KW - Adipose Tissue/chemistry
KW - Aged
KW - Biomarkers, Tumor/analysis
KW - Female
KW - Humans
KW - Lymphoma, Non-Hodgkin/chemically induced
KW - Male
KW - Middle Aged
KW - Polychlorinated Biphenyls/analysis
KW - Proportional Hazards Models
KW - Prospective Studies
U2 - 10.1158/1055-9965.EPI-17-0937
DO - 10.1158/1055-9965.EPI-17-0937
M3 - Journal article
C2 - 29254933
SN - 1055-9965
VL - 27
SP - 224
EP - 226
JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
IS - 2
ER -