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No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland

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  2. Gestational diabetes and macrosomia among Greenlanders. Time to change diagnostic strategy?

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  3. Gonorrhoea in Greenland: geographic differences in diagnostic activity and incidence of gonorrhoea in 2015

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  4. Validation of cardiovascular diagnoses in the Greenlandic Hospital Discharge Register for epidemiological use

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gestational Diabetes Risk in Migrants. A Nationwide, Register-Based Study of all Births in Denmark 2004 to 2015

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Migration, body mass index and gestational diabetes mellitus among women in Denmark 2004-2015: a register-based study

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  3. Migration, body mass index and gestational diabetes mellitus among women in Denmark 2004-2015: a register-based study

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Vis graf over relationer

Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring's birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring's birthweight among predominantly indigenous women in Greenland. A retrospective cohort study including all women (n = 503) and their offspring delivered from September 2015 to September 2016 at Queen Ingrid's Hospital in Nuuk was conducted. Data were obtained from the electronic medical record. Linear regression models were used to analyse the effect of maternal HbA1c on the offspring's birthweight with adjustment and stratification for relevant confounders and effect modifiers. Birthweight increased with 3.3 g per mmol/mol increase in HbA1c. Yet, no significant association between maternal HbA1c and the offspring's birthweight was found after adjustment for maternal age, ethnicity, residence, smoking, and parity (β = 0.058, p = 0.711). Among obese women, a borderline significant positive association (β = 0.657, p = 0.059) was found. For term newborns, this corresponded to an increase in birthweight of 31 g per mmol/mol increase in HbA1c. Based on the current study, the use of HbA1c during pregnancy to detect the risk of delivering a newborn with macrosomia is not recommended in Greenland.Abbreviation: HbA1c: glycosylated haemoglobin; GA: gestational age; SD: standard deviation; CI: confidence interval.

OriginalsprogEngelsk
Artikelnummer1702798
TidsskriftInternational Journal of Circumpolar Health
Vol/bind79
Udgave nummer1
ISSN1239-9736
DOI
StatusUdgivet - 11 dec. 2019

ID: 58644628