TY - JOUR
T1 - Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation
AU - Ramachandran, Roshni
AU - Bhatt, Deepak Kumar
AU - Ploug, Kenneth Beri
AU - Hay-Schmidt, Anders
AU - Jansen-Olesen, Inger
AU - Gupta, Saurabh
AU - Olesen, Jes
PY - 2014/2
Y1 - 2014/2
N2 - Infusion of glyceryltrinitrate (GTN), a nitric oxide (NO) donor, in awake, freely moving rats closely mimics a universally accepted human model of migraine and responds to sumatriptan treatment. Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN-induced neuronal activation in this model.
AB - Infusion of glyceryltrinitrate (GTN), a nitric oxide (NO) donor, in awake, freely moving rats closely mimics a universally accepted human model of migraine and responds to sumatriptan treatment. Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN-induced neuronal activation in this model.
U2 - 10.1177/0333102413502735
DO - 10.1177/0333102413502735
M3 - Journal article
C2 - 24000375
SN - 0333-1024
VL - 34
SP - 136
EP - 147
JO - Cephalalgia : an international journal of headache
JF - Cephalalgia : an international journal of headache
IS - 2
ER -