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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Next generation microbiology and cystic fibrosis diagnostics: are we there yet?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  2. Obesity and asthma: current knowledge and future needs

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  3. Respiratory bacterial infections in cystic fibrosis

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  4. Stenotrophomonas maltophilia: to be or not to be a cystic fibrosis pathogen

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  5. Screening for lung cancer: are we there yet?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hydrochloric acid prolongs the lifetime of central venous catheters in haematologic patients with bacteraemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-Term Outcomes of Partial Oral Treatment of Endocarditis

    Publikation: Bidrag til tidsskriftLetterForskning

  3. Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis

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PURPOSE OF REVIEW: The major problem for cystic fibrosis patients is the recurrent and chronic infections of the lungs, determining their prognosis. The challenge from biofilm-growing bacteria and emerging viruses urge the microbiological laboratories to develop better and faster diagnostic tools. Of these, molecular diagnostics are rapidly developing. However, beyond detecting many microorganisms, the task is to evaluate their clinical significance. This has always been a problem resulting in Koch's postulates. Then, the task was to distinguish the offending pathogens from the normal flora, as today, however, the normal flora is renamed microbiota.

RECENT FINDINGS: This review includes the most recent studies on molecular diagnostics of viral and bacterial infections in cystic fibrosis. Generally, molecular methods have revolutionized virus and bacterial detection, and species-specific and multiplex molecular methods are valuable. However, the large amount of data obtained from new sequencing techniques challenge the interpretation and evaluation of clinical relevance.

SUMMARY: More research is needed to discriminate offending pathogens from contaminating microbiota and to be able to identify the anatomical origin of the many detected microbes. Furthermore, the sequencing techniques must report all the detected microbes to the species level to allow the clinician to evaluate the properties of the microbes being relevant for the infection.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Pulmonary Medicine
Vol/bind24
Udgave nummer6
Sider (fra-til)599-605
Antal sider7
ISSN1070-5287
DOI
StatusUdgivet - nov. 2018

ID: 56232129