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New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

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Enevoldsen, Majken ; Henneberg, K-A ; Jensen, J A ; Lönn, L ; Humphrey, J D. / New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model. I: Journal of Biomechanics. 2011 ; Bind 44, Nr. 6. s. 1209-11.

Bibtex

@article{664d4df8a2324f6f9be2a0502dc02d7a,
title = "New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model",
abstract = "Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated {"}four fiber family{"} constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries.",
keywords = "Animals, Aortic Aneurysm, Abdominal, Arteries, Atherosclerosis, Collagen, Humans, Models, Cardiovascular, Rats, Rats, Sprague-Dawley, Smoking",
author = "Majken Enevoldsen and K-A Henneberg and Jensen, {J A} and L L{\"o}nn and Humphrey, {J D}",
note = "Copyright {\circledC} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/j.jbiomech.2011.01.032",
language = "English",
volume = "44",
pages = "1209--11",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Pergamon",
number = "6",

}

RIS

TY - JOUR

T1 - New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

AU - Enevoldsen, Majken

AU - Henneberg, K-A

AU - Jensen, J A

AU - Lönn, L

AU - Humphrey, J D

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011

Y1 - 2011

N2 - Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated "four fiber family" constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries.

AB - Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated "four fiber family" constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries.

KW - Animals

KW - Aortic Aneurysm, Abdominal

KW - Arteries

KW - Atherosclerosis

KW - Collagen

KW - Humans

KW - Models, Cardiovascular

KW - Rats

KW - Rats, Sprague-Dawley

KW - Smoking

U2 - 10.1016/j.jbiomech.2011.01.032

DO - 10.1016/j.jbiomech.2011.01.032

M3 - Journal article

VL - 44

SP - 1209

EP - 1211

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 6

ER -

ID: 33198162